Abstract Cucurbitacin B (CuB, C 32 H 46 O 8), the most abundant and active member of
cucurbitacins, which are highly oxidized tetracyclic triterpenoids. Cucurbitacins are widely …

Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic
transcription factors that mediate intracellular signaling that is usually generated at cell …

Introduction: Terpenoids constitute the largest class of natural products and are a rich
reservoir of candidate compounds for drug discovery. Recent efforts into the research and …

Ethnopharmacological relevance Citrullus colocynthis (L.) Schrad is a valuable cucurbit
plant, widely distributed in the desert areas of the world. Citrullus colocynthis fruits are …

Pancreatic cancer is an aggressive malignancy that is generally refractory to chemotherapy,
thus posing experimental and clinical challenges. In this study, the antiproliferative effect of …

Triterpenoids are ubiquitous in the plant kingdom. Recent evidences support the beneficial
effects of naturallyoccurring triterpenoids against several types of human diseases, including …

Cucurbitacin B is an anti-cancer drug candidate and its efficacy has been demonstrated in
hepatocellular carcinoma (HCC). To explore its mechanism against HCC, BEL-7402 cells …

Gliomas are the most malignant and aggressive primary brain tumor in adults. Despite
concerted efforts to improve therapies, their prognosis remains very poor. Isocitrate …

New therapies using novel mechanisms to induce tumor cell death are needed with plants
playing a crucial role as a source for potential anticancer compounds. One highly promising …

Cucurbitacins and their derivatives are triterpenoids found in medicinal plants known for
their diverse pharmacological and biological activities, including anticancer effects …