Drug discovery and development is a complex and costly process. Machine learning
approaches are being investigated to help improve the effectiveness and speed of multiple …

The human leukocyte antigen (HLA) super-locus is a genomic region in the chromosomal
position 6p21 that encodes the six classical transplantation HLA genes and at least 132 …

Genes underneath signals from genome-wide association studies (GWAS) for kidney
function are promising targets for functional studies, but prioritizing variants and genes is …

Alzheimer's disease (AD) is characterized by severe neuronal loss; however, the
mechanisms by which neurons die remain elusive. Necroptosis, a programmed form of …

Background System-wide profiling of genes and proteins in mammalian cells produce lists of
differentially expressed genes/proteins that need to be further analyzed for their collective …

Structural Variations (SV) are a major source of variability in the human genome that shaped
its actual structure during evolution. Moreover, many human diseases are caused by SV …

Biomedical knowledge graphs (KGs), which can help with the understanding of complex
biological systems and pathologies, have begun to play a critical role in medical practice …

MicroRNAs are small, non-coding RNA molecules that can complementarily bind to the
mRNA 3′-UTR region to regulate the gene expression by transcriptional repression or …

Background Mapping of orthologous genes among species serves an important role in
functional genomics by allowing researchers to develop hypotheses about gene function in …

DNA transfer from cytoplasmic organelles to the cell nucleus is a legacy of the
endosymbiotic event—the majority of nuclear-mitochondrial segments (NUMTs) are thought …