Overview of the materials design and sensing strategies of nanopore devices

L Liang, F Qin, S Wang, J Wu, R Li, Z Wang… - Coordination Chemistry …, 2023 - Elsevier
Nanopore platform holds a great fascination that attracts increasing interests in research and
leads the development of various domains. Herein we first briefly introduce the …

Electroosmosis in nanopores: computational methods and technological applications

A Gubbiotti, M Baldelli, G Di Muccio… - … in Physics: X, 2022 - Taylor & Francis
Electroosmosis is a fascinating effect where liquid motion is induced by an applied electric
field. Counter ions accumulate in the vicinity of charged surfaces, triggering a coupling …

[HTML][HTML] Protein identification by nanopore peptide profiling

FLR Lucas, RCA Versloot, L Yakovlieva… - Nature …, 2021 - nature.com
Nanopores are single-molecule sensors used in nucleic acid analysis, whereas their
applicability towards full protein identification has yet to be demonstrated. Here, we show …

Machine Learning Assisted Simultaneous Structural Profiling of Differently Charged Proteins in a Mycobacterium smegmatis Porin A (MspA) Electroosmotic Trap

Y Liu, K Wang, Y Wang, L Wang, S Yan… - Journal of the …, 2022 - ACS Publications
The nanopore is emerging as a means of single-molecule protein sensing. However,
proteins demonstrate different charge properties, which complicates the design of a sensor …

Protein Sizing with 15 nm Conical Biological Nanopore YaxAB

S Straathof, G Di Muccio, M Yelleswarapu… - ACS …, 2023 - ACS Publications
Nanopores are promising single-molecule tools for the electrical identification and
sequencing of biomolecules. However, the characterization of proteins, especially in real …

Optical nanopore sensors for quantitative analysis

JP Fried, Y Wu, RD Tilley, JJ Gooding - Nano Letters, 2022 - ACS Publications
Nanopore sensors have received significant interest for the detection of clinically important
biomarkers with single-molecule resolution. These sensors typically operate by detecting …

β-Barrel nanopores with an acidic–aromatic sensing region identify proteinogenic peptides at low pH

RCA Versloot, SAP Straathof, G Stouwie, MJ Tadema… - ACS …, 2022 - ACS Publications
Biological nanopores are emerging as sensitive single-molecule sensors for proteins and
peptides. The heterogeneous charge of a polypeptide chain, however, can complicate or …

[HTML][HTML] Biological nanopores: Engineering on demand

A Crnković, M Srnko, G Anderluh - Life, 2021 - mdpi.com
Nanopore-based sensing is a powerful technique for the detection of diverse organic and
inorganic molecules, long-read sequencing of nucleic acids, and single-molecule analyses …

The manipulation of the internal hydrophobicity of FraC nanopores augments peptide capture and recognition

FLR Lucas, K Sarthak, EM Lenting, D Coltan… - ACS …, 2021 - ACS Publications
The detection of analytes and the sequencing of DNA using biological nanopores have seen
major advances over recent years. The analysis of proteins and peptides with nanopores …

Recent advances in nanotechnologies combining surface-enhanced Raman scattering and nanopore

HL Liu, K Zhan, K Wang, XH Xia - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Tremendous efforts have been dedicated to detect single-molecule based on nanopore
technologies. The electrochemical method is now the most widely-used detection scheme of …