Ischemic stroke after cerebral artery occlusion is one of the major causes of chronic disability
worldwide. Interleukins (ILs) play a bidirectional role in ischemic stroke through information …

Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …

Ischemic stroke generates an immune response that contributes to neuronal loss as well as
tissue repair. This is a complex process involving a range of cell types and effector …

Neuroimmunology, albeit a relatively established discipline, has recently sparked numerous
exciting findings on microglia, the resident macrophages of the central nervous system …

Immunity and inflammation are key elements of the pathobiology of stroke, a devastating
illness second only to cardiac ischemia as a cause of death worldwide. The immune system …

Interleukin-10 (IL-10) is an important anti-inflammatory cytokine expressed in response to
brain injury, where it facilitates the resolution of inflammatory cascades, which if prolonged …

Neurodegenerative diseases of the central nervous system (CNS) are characterized by
progressive neuronal death and neurological dysfunction, leading to increased disability …

Abstract Interleukin-10 and Interleukin-12 are produced primarily by pathogen-activated
antigen-presenting cells, particularly macrophages and dendritic cells. IL-10 and IL-12 play …

Background and Purpose—Ischemic stroke leads to significant morbidity and mortality in the
Western world. Early reperfusion strategies remain the treatment of choice but can initiate …

Systemic and local inflammatory processes have a key, mainly detrimental role in the
pathophysiology of ischemic stroke. Currently, little is known about endogenous …