The slow death of the concept of schizophrenia and the painful birth of the psychosis spectrum

S Guloksuz, J van Os - Psychological medicine, 2018 - cambridge.org
The concept of schizophrenia only covers the 30% poor outcome fraction of a much broader
multidimensional psychotic syndrome, yet paradoxically has become the dominant prism …

Association of psychotic experiences with subsequent risk of suicidal ideation, suicide attempts, and suicide deaths: a systematic review and meta-analysis of …

K Yates, U Lång, M Cederlöf, F Boland, P Taylor… - JAMA …, 2019 - jamanetwork.com
Importance Recent research has highlighted that psychotic experiences are far more
prevalent than psychotic disorders and associated with the full range of mental disorders. A …

A critique of the “ultra‐high risk” and “transition” paradigm

J Van Os, S Guloksuz - World Psychiatry, 2017 - Wiley Online Library
The transdiagnostic expression of psychotic experiences in common mental disorder
(anxiety/depression/substance use disorder) is associated with a poorer prognosis, and a …

Major depressive disorder in DSM‐5: Implications for clinical practice and research of changes from DSM‐IV

R Uher, JL Payne, B Pavlova… - Depression and …, 2014 - Wiley Online Library
The changes in diagnostic criteria for major depressive disorder (MDD) from the fourth to the
fifth edition of the D iagnostic and S tatistical M anual of M ental D isorders (DSM) may …

Comorbid depressive and anxiety disorders in 509 individuals with an at-risk mental state: impact on psychopathology and transition to psychosis

P Fusar-Poli, B Nelson, L Valmaggia… - Schizophrenia …, 2014 - academic.oup.com
Background: The current diagnostic system for subjects at enhanced clinical risk of
psychosis allows concurrent comorbid diagnoses of anxiety and depressive disorders. Their …

Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2008 British Association for Psychopharmacology guidelines

A Cleare, CM Pariante, AH Young… - Journal of …, 2015 - journals.sagepub.com
A revision of the 2008 British Association for Psychopharmacology evidence-based
guidelines for treating depressive disorders with antidepressants was undertaken in order to …

Evidence that psychotic symptoms are prevalent in disorders of anxiety and depression, impacting on illness onset, risk, and severity—implications for diagnosis and …

JTW Wigman, M van Nierop… - Schizophrenia …, 2012 - academic.oup.com
Background: It is commonly assumed that there are clear lines of demarcation between
anxiety and depressive disorders on the one hand and psychosis on the other. Recent …

[HTML][HTML] Treating comorbid anxiety and depression: Psychosocial and pharmacological approaches

JD Coplan, CJ Aaronson, V Panthangi… - World journal of …, 2015 - ncbi.nlm.nih.gov
Comorbid anxiety with depression predicts poor outcomes with a higher percentage of
treatment resistance than either disorder occurring alone. Overlap of anxiety and depression …

Lessons learned from the psychosis high-risk state: towards a general staging model of prodromal intervention

P Fusar-Poli, AR Yung, P McGorry… - Psychological medicine, 2014 - cambridge.org
BackgroundThe past two decades have seen exponential clinical and research interest in
help-seeking individuals presenting with potentially prodromal symptoms for psychosis …

Introduction: the extended psychosis phenotype—relationship with schizophrenia and with ultrahigh risk status for psychosis

J Van Os, RJ Linscott - Schizophrenia bulletin, 2012 - academic.oup.com
227 important clinical consequences for the outcome of these disorders, 16 reinforcing the
view that psychopathology is represented by a network of overlapping and reciprocally …