As the discovery of the Alzheimer's disease (AD) genes, APP, PSEN1, and PSEN2, in
families with autosomal dominant early-onset AD (EOAD), gene discovery in familial EOAD …

Alzheimetr's disease (AD) is the fourth major cause of death in the developed world after
heart disease, cancer and stroke. It is largely, but not exclusively, a disease of the elderly …

A LOCUS segregating with familial Alzheimer's disease (AD) has been mapped to
chromosome 21 (ref. 1), close to the amyloid precursor protein (APP) gene2–5 …

Apolipoprotein E, type ϵ4 allele (APOE ϵ4), is associated with late-onset familial
Alzheimer's disease (AD). There is high avidity and specific binding of amyloid β-peptide …

Perhaps no disorder of the human brain has aroused more interest among neuroscientists in
recent years than Alzheimer's disease (AD). This common and devastating cerebral …

Some cases of Alzheimer's disease are inherited as an autosomal dominant trait. Genetic
linkage studies have mapped a locus (AD3) associated with susceptibility to a very …

One hundred years ago a small group of psychiatrists described the abnormal protein
deposits in the brain that define the most common neurodegenerative diseases. Over the …

Medical genetics was revolutionized during the 1980s by the application of genetic mapping
to locate the genes responsible for simple Mendelian diseases. Most diseases and traits …

Alzheimer disease and type 2 diabetes are characterized by increased prevalence with
aging, a genetic predisposition, and comparable pathological features in the islet and brain …

The first and still the only book of its kind, this volume offers a concise introduction to human
genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical …