Carbohydrates—namely glycans—decorate every cell in the human body and most secreted
proteins. Advances in genomics, glycoproteomics and tools from chemical biology have …

CD24 is a highly glycosylated protein with a small protein core that is linked to the plasma
membrane via a glycosyl‐phosphatidylinositol anchor. CD24 is primarily expressed by …

Small interfering RNA (siRNA) is a powerful tool for gene silencing that has been used for a
wide range of biomedical applications, but there are many challenges facing its therapeutic …

During malignant transformation, glycosylation is heavily altered compared with healthy
tissue due to differential expression of glycosyltransferases, glycosidases and …

Cancer immunotherapy in the form of immune checkpoint inhibitors and cellular therapies
has improved the treatment and prognosis of many patients. Nevertheless, most cancers are …

Tumor cells transit from the primary tumor via the blood circulation to form metastases in
distant organs. During this process, tumor cells encounter a number of environmental …

Malignant transformation of cells is associated with aberrant glycosylation presented on the
cell-surface. Commonly observed changes in glycan structures during malignancy …

Cluster of differentiation 24 (CD24) is a small, highly glycosylated cell adhesion protein that
is normally expressed by immune as well as epithelial, neural, and muscle cells. Tumor …

Cancer metastasis is facilitated by cell–cell interactions between cancer cells and
endothelial cells in distant tissues. In addition, cancer cell interactions with platelets and …

Vestweber, Dietmar, and James E. Blanks. Mechanisms That Regulate the Function of the
Selectins and Their Ligands. Physiol. Rev. 79: 181–213, 1999.—Selectins are a family of …