Sirtuins are a class of NAD+-dependent deacetylases having beneficial health effects. This
extensive review describes the numerous intracellular actions of the seven mammalian …

Sirtuins are stress‐responsive proteins that direct various post‐translational modifications
(PTM s) and as a result, are considered to be master regulators of several cellular …

A molecule that treats multiple age-related diseases would have a major impact on global
health and economics. The SIRT1 deacetylase has drawn attention in this regard as a target …

Over the past decade, endoplasmic reticulum (ER) stress has emerged as an important
mechanism involved in the pathogenesis of cardiovascular diseases including heart failure …

Ovarian aging is characterized by gradual declines in oocyte quantity and quality. Melatonin
is considered an anti‐aging agent due to its cytoprotective actions as an antioxidant. This …

Microplastics (MPs) pollution poses an emerging threat to aquatic biota, which could hinder
their physiological processes. Recently various evidence has demonstrated the toxic …

Background Cancer cells are characterized by uncontrolled cell proliferation and impaired
bioenergetics. Sirtuins are a family of highly conserved enzymes that play a fundamental …

Melatonin is a lipophilic hormone synthesized and secreted mainly in the pineal gland,
acting as a neuroendocrine transducer of photoperiodic information during the night. In …

Perturbation of metabolism elicits cellular stress which profoundly modulates the cellular
proteome and thus protein homeostasis (proteostasis). Consequently, changes in the …

Incidence of HPV+ oropharyngeal squamous cell carcinoma (OPSCC) has been increasing
dramatically. Although long-term survival rates for these patients are high, they often suffer …