[HTML][HTML] miRNA-based biomarkers, therapies, and resistance in Cancer

B He, Z Zhao, Q Cai, Y Zhang, P Zhang… - … journal of biological …, 2020 - ncbi.nlm.nih.gov
Abstract MicroRNAs (miRNAs), small non-coding RNAs (ncRNAs) of about 22 nucleotides in
size, play important roles in gene regulation, and their dysregulation is implicated in human …

Non-coding RNA in cancer drug resistance: Underlying mechanisms and clinical applications

X Zhou, X Ao, Z Jia, Y Li, S Kuang, C Du… - Frontiers in …, 2022 - frontiersin.org
Cancer is one of the most frequently diagnosed malignant diseases worldwide, posing a
serious, long-term threat to patients' health and life. Systemic chemotherapy remains the first …

lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/β-catenin signaling

J Pan, S Fang, H Tian, C Zhou, X Zhao, H Tian, J He… - Molecular cancer, 2020 - Springer
Abstract Background MicroRNAs (miRNAs) and Twist1-induced epithelial-mesenchymal
transition (EMT) in cancer cell dissemination are well established, but the involvement of …

Updated review of advances in microRNAs and complex diseases: experimental results, databases, webservers and data fusion

L Huang, L Zhang, X Chen - Briefings in bioinformatics, 2022 - academic.oup.com
MicroRNAs (miRNAs) are gene regulators involved in the pathogenesis of complex
diseases such as cancers, and thus serve as potential diagnostic markers and therapeutic …

Advances in genomic data and biomarkers: revolutionizing NSCLC diagnosis and treatment

JC Restrepo, D Dueñas, Z Corredor, Y Liscano - Cancers, 2023 - mdpi.com
Simple Summary In the field of non-small cell lung cancer (NSCLC), there have been
significant advancements in genomic data and bioinformatics tools, which have improved …

The role of MiRNA in cancer: pathogenesis, diagnosis, and treatment

E Uzuner, GT Ulu, SB Gürler, Y Baran - miRNomics: MicroRNA Biology …, 2022 - Springer
Cancer is also determined by the alterations of oncogenes and tumor suppressor genes.
These gene expressions can be regulated by microRNAs (miRNA). At this point, researchers …

Evaluating the use of circulating microRNA profiles for lung cancer detection in symptomatic patients

T Fehlmann, M Kahraman, N Ludwig, C Backes… - JAMA …, 2020 - jamanetwork.com
Importance The overall low survival rate of patients with lung cancer calls for improved
detection tools to enable better treatment options and improved patient outcomes …

Blood-based liquid biopsy: Insights into early detection and clinical management of lung cancer

C Liu, X Xiang, S Han, HY Lim, L Li, X Zhang, Z Ma… - Cancer Letters, 2022 - Elsevier
Currently, early detection of lung cancer relies on the characterisation of images generated
from computed tomography (CT). However, lung tissue biopsy, a highly invasive surgical …

Development of a serum miRNA panel for detection of early stage non-small cell lung cancer

L Ying, L Du, R Zou, L Shi, N Zhang… - Proceedings of the …, 2020 - National Acad Sciences
Minimally invasive testing for early detection of lung cancer to improve patient survival is a
major unmet clinical need. This study aimed to develop and validate a serum multi …

Diagnostic, predictive, and prognostic biomarkers in non-small cell lung cancer (NSCLC) management

M Šutić, A Vukić, J Baranašić, A Försti… - Journal of personalized …, 2021 - mdpi.com
Lung cancer is the leading cause of cancer-related deaths worldwide. Despite growing
efforts for its early detection by screening populations at risk, the majority of lung cancer …