Biologics such as monoclonal antibodies are much more complex than small-molecule
drugs, which raises challenging questions for the development and regulatory evaluation of …

In metazoans, histone mRNAs are not polyadenylated but end in a conserved stem-loop.
Stem-loop binding protein (SLBP) binds to the stem-loop and is required for all steps in …

Protein phosphorylation plays vital roles in biological processes, and some phosphorylated
proteins are important biomarkers. However, the concentration of these biomarkers in …

Introduction In proteomics a paradox situation developed in the last years. At one side it is
basic knowledge that proteins are post-translationally modified and occur in different …

Post-translational modification of proteins is important for the regulation of cellular
processes, including the cellular localization of protein, the regulation of protein function …

Metazoan replication-dependent histone messenger RNAs (mRNAs) have a conserved
stem-loop (SL) at their 3′-end. The stem-loop binding protein (SLBP) specifically …

Over the last years, top‐down (TD) MS has gained a remarkable space in proteomics,
rapidly trespassing the limit between a promising approach and a solid, established …

Over 100 mutations in Cu/Zn-superoxide dismutase (SOD1) result in familial amyotrophic
lateral sclerosis. Dimer dissociation is the first step in SOD1 aggregation, and studies …

RNA hairpins are the most commonly occurring secondary structural elements in RNAs and
serve as nucleation sites for RNA folding, RNA–RNA, and RNA–protein interactions. RNA …

Ribonucleoprotein complexes involved in pre-mRNA splicing and mRNA decay are often
regulated by phosphorylation of RNA-binding proteins. Cells use phosphorylation …