Gastrointestinal tract polyposis is characterised by the presence of multiple polyps,
particularly in the colorectum, and encompasses both cancer predisposition genetic …

The most prevalent type of intestinal polyposis, colorectal adenomatous polyposis (CAP), is
regarded as a precancerous lesion of colorectal cancer with obvious genetic characteristics …

Only a few patients with germline AXIN2 variants and colorectal adenomatous polyposis or
cancer have been described, raising questions about the actual contribution of this gene to …

Importance There is some evidence that tooth agenesis (congenital absence of 1 or more
teeth) is associated with cancer risk, especially carcinomas of the colon and ovaries, but …

Background There is a lack of information on rare germline variants of pancreatic cancer-
predisposing genes. Risk genes for multiple primary cancers may overlap with those for …

Several professional society guidelines suggest germline genetic testing for colorectal
polyposis syndromes in patients with≥ 10 lifetime adenomatous polyps. This study …

In the age of telehealth medicine, an individual's facial features may provide the only
physical clues signaling the presence of a heritable cancer predisposition syndrome. These …

Background WNT signaling is pivotal in embryogenesis and tissue homeostasis. Aberrant
WNT signaling, due to mutations in components of this pathway, contributes to the …

Hereditary polyposis syndromes are significant contributors to colorectal cancer (CRC).
These syndromes are characterized by the development of various types and numbers of …

Background Hereditary adenomatous polyposis syndromes, including familial adenomatous
polyposis and other rare adenomatous polyposis syndromes, increase the lifetime risk of …