Exploring the efficacy of natural products in alleviating Alzheimer's disease

P Deshpande, N Gogia, A Singh - Neural regeneration research, 2019 - journals.lww.com
Alzheimer's disease (hereafter AD) is a progressive neurodegenerative disorder that affects
the central nervous system. There are multiple factors that cause AD, viz., accumulation of …

[HTML][HTML] Insights into regeneration tool box: An animal model approach

AS Mehta, A Singh - Developmental biology, 2019 - Elsevier
For ages, regeneration has intrigued countless biologists, clinicians, and biomedical
engineers. In recent years, significant progress made in identification and characterization of …

The Hippo pathway effector Yki downregulates Wg signaling to promote retinal differentiation in the Drosophila eye

E Wittkorn, A Sarkar, K Garcia, M Kango-Singh… - …, 2015 - journals.biologists.com
The evolutionarily conserved Hippo signaling pathway is known to regulate cell proliferation
and maintain tissue homeostasis during development. We found that activation of Yorkie …

Hippo signaling: bridging the gap between cancer and neurodegenerative disorders

N Gogia, AV Chimata, P Deshpande… - Neural Regeneration …, 2021 - journals.lww.com
During development, regulation of organ size requires a balance between cell proliferation,
growth and cell death. Dysregulation of these fundamental processes can cause a variety of …

Genetic mechanism regulating diversity in the placement of eyes on the head of animals

OR Puli, N Gogia, AV Chimata… - Proceedings of the …, 2024 - National Acad Sciences
Despite the conservation of genetic machinery involved in eye development, there is a
strong diversity in the placement of eyes on the head of animals. Morphogen gradients of …

Cullin-4 regulates Wingless and JNK signaling-mediated cell death in the Drosophila eye

M Tare, A Sarkar, S Bedi, M Kango-Singh… - Cell Death & …, 2016 - nature.com
In all multicellular organisms, the fundamental processes of cell proliferation and cell death
are crucial for growth regulation during organogenesis. Strict regulation of cell death is …

Molecular genetic mechanisms of axial patterning: mechanistic insights into generation of axes in the developing eye

M Tare, O Roy Puli, A Singh - … genetics of axial patterning, growth and …, 2013 - Springer
All multicellular organisms require axial patterning to transform a single-layer organ
primordium to a three-dimensional organ. It involves delineation of anteroposterior (AP) …

Generation of Third Dimension: Axial Patterning in the Developing Drosophila Eye

N Gogia, OR Puli, A Raj, A Singh - … Growth and Disease in Drosophila Eye, 2020 - Springer
Axial patterning, a fundamental process during organogenesis, is required for transition of a
single layer organ primordium to a three-dimensional organ in all multi-cellular organisms …

Proximal fate marker homothorax marks the lateral extension of stalk‐eyed fly Cyrtodopsis whitei

A Singh, N Gogia, CY Chang, YH Sun - genesis, 2019 - Wiley Online Library
The placement of eyes on insect head is an important evolutionary trait. The stalk‐eyed fly,
Cyrtodopsis whitei, exhibits a hypercephaly phenotype where compound eyes are located …

Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye

H Zhao, KH Moberg, A Veraksa - Developmental cell, 2023 - cell.com
The canonical function of the Hippo signaling pathway is the regulation of organ growth.
How this pathway controls cell-fate determination is less well understood. Here, we identify a …