Neural substrates of wakefulness, rapid eye movement sleep (REMS), and non-REMS
(NREMS) in the mammalian hypothalamus overlap both anatomically and functionally with …

The orexin/hypocretin neuropeptide family has emerged as a focal point of neuroscientific
research following the discovery that this family plays a crucial role in a variety of …

Metabolic health depends on the brain's ability to control food intake and nutrient use versus
storage, processes that require peripheral signals such as the adipocyte-derived hormone …

Early-life determinants are thought to be a major factor in the rapid increase of obesity.
However, while maternal nutrition has been extensively studied, the effects of breastfeeding …

Altered methionine metabolism is associated with weight gain in obesity. The methionine
adenosyltransferase (MAT), catalyzing the first reaction of the methionine cycle, plays an …

The lateral septum (LS) has been implicated in the regulation of locomotion. Nevertheless,
the neurons synchronizing LS activity with the brain's clock in the suprachiasmatic nucleus …

Objective The development of effective anti-obesity therapeutics relies heavily on the ability
to target specific brain homeostatic and hedonic mechanisms controlling body weight. To …

Background Increased physical activity is a common feature of anorexia nervosa (AN).
Although high activity levels are associated with greater risk of developing AN, particularly …

Understanding how dopamine (DA) encodes behavior depends on technologies that can
reliably monitor DA release in freely-behaving animals. Recently, red and green genetically …

In multicellular organisms, neurons integrate a diverse array of external cues to affect
downstream changes in organismal health. Specifically, activation of the endoplasmic …