[HTML][HTML] The long and winding road of reprogramming-induced rejuvenation
AD Yücel, VN Gladyshev - Nature Communications, 2024 - nature.com
Organismal aging is inherently connected to the aging of its constituent cells and systems.
Reducing the biological age of the organism may be assisted by reducing the age of its cells …
Reducing the biological age of the organism may be assisted by reducing the age of its cells …
Nature of epigenetic aging from a single-cell perspective
Age-related changes in DNA methylation (DNAm) form the basis of the most robust
predictors of age—epigenetic clocks—but a clear mechanistic understanding of exactly …
predictors of age—epigenetic clocks—but a clear mechanistic understanding of exactly …
Neuron-specific chromatin disruption at CpG islands and aging-related regions in Kabuki syndrome mice
Many Mendelian developmental disorders caused by coding variants in epigenetic
regulators have now been discovered. Epigenetic regulators are broadly expressed, and …
regulators have now been discovered. Epigenetic regulators are broadly expressed, and …
[HTML][HTML] Somatic mutation as an explanation for epigenetic aging
DNA methylation marks have recently been used to build models known as “epigenetic
clocks” which predict calendar age. As methylation of cytosine promotes C-to-T mutations …
clocks” which predict calendar age. As methylation of cytosine promotes C-to-T mutations …
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C Galicia, M Marinova - vitadao.com
Scientists are forever searching for ways to rejuvenate aged cells and organisms back to a
more youthful and healthier state—from stem cell therapies to telomere lengthening, or even …
more youthful and healthier state—from stem cell therapies to telomere lengthening, or even …