The role of tissue factor (TF) in inflammation is mediated by blood coagulation. TF initiates
the extrinsic blood coagulation that proceeds as an extracellular signaling cascade by a …

Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic agent, proven in
clinical trials to be both safe in inflammatory bowel disease (PL-10, PLD-116, PL 14736) and …

Abstract Background: The cyclooxygenase-2 (COX-2) inhibitor celecoxib is thought to act as
a chemopreventive agent by sensitizing cancer cells to apoptotic signals. Other COX-2 …

Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic agent, safe in
inflammatory bowel disease clinical trials (GEPPPGKPADDAGLV, MW 1419, PL 14736) and …

AIMS: We attempted to fully antagonize the extensive toxicity caused by NSAIDs (using
diclofenac as a prototype). MAIN METHODS: Herein, we used the stable gastric …

Angiogenesis, the formation of new capillary blood vessels, is a fundamental process
essential for reproduction and embryonic development. It is crucial to the healing of tissue …

The purpose of this study was to determine whether budesonide–and indomethacin–
hydroxypropyl-β-cyclodextrin (HPBCD) complexes could be formed using a supercritical …

NF-κ B activity is elevated in a high proportion of cancers, particularly advanced cancers that
have been treated previously. Cytotoxic treatment selects for such up-regulation inasmuch …

Microsomal prostaglandin E synthase-1 (mPGES-1) catalyzes the conversion of
cyclooxygenase-derived prostaglandin (PG) H 2 to PGE 2. Increased amounts of mPGES-1 …

The stomach plays a pivotal role in the digestion of foods that we eat. With the exception of
rare cases, this organ can resist to a large variety of noxious factors, including hydrochloric …