The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Ocular coloboma is a congenital disorder of the eye where a gap exists in the inferior retina,
lens, iris, or optic nerve tissue. With a prevalence of 2–19 per 100,000 live births, coloboma …

Background Congenital ocular anomalies (COA) are among the most common causes of
visual impairment in children in high‐income countries. The aim of the study is to describe …

The estimated prevalence of permanent bilateral hearing loss (HL) in children is 1.33 per
1000 live births, increasing to 3.5 per 1000 adolescents, presumably reflecting additional …

Purpose The aim of this study is to describe and compare the baseline demographic, ocular,
and imaging characteristics of a cohort of patients with optic disc pit (ODP) or optic disc …

A key embryonic process that occurs early in ocular development is optic fissure closure
(OFC). This fusion process closes the ventral optic fissure and completes the circumferential …

Abstract The inaugural Aniridia North America (ANA) Symposium was held on the first
weekend in November 2021 in Charlottesville, VA, at the University of Virginia. The purpose …

Ocular coloboma (OC) is a congenital disorder caused by the incomplete closure of the
embryonic ocular fissure. OC can present as a simple anomaly or, in more complex forms …

Genetic and environmental factors can independently or coordinatively drive ocular axis
growth. Mutations in FRIZZLED5 (FZD5) have been associated with microphthalmia …

This article deals with congenital lesions involving the pediatric globe. A sizable proportion
of children with ocular lesions present with leukocoria, that is, loss of the normal red reflex …