Despite continuous advances in understanding the underlying pathogenesis of
hyperexcitable networks and lowered seizure thresholds, the treatment of epilepsy remains …

Different studies have confirmed P2X7 receptor-mediated inflammatory mediators play a key
role in the development of pain. P2X7 receptor activation can induce the development of …

Epilepsy is one of the most common and disabling chronic neurological diseases affecting
people of all ages. Major challenges of epilepsy management include the persistently high …

Hyperinflammation plays an important role in severe and critical COVID-19. Using
inconsistent criteria, many researchers define hyperinflammation as a form of very severe …

Hyperglycemia is a risk factor for poor prognosis after acute ischemic stroke and promote the
occurrence of hemorrhagic transformation (HT). The activation of P2RX7 play an important …

Mounting evidence suggests that the ATP-gated P2X7 receptor contributes to increased
hyperexcitability in the brain. While increased expression of P2X7 in the hippocampus and …

Epilepsy is a chronic neurological disorder that has an extensive impact on a patient's life.
Accumulating evidence has suggested that inflammation participates in the progression of …

Epilepsy, characterized by recurrent spontaneous seizures, is a heterogeneous group of
brain diseases affecting over 70 million people worldwide. Major challenges in the …

Abstract Treatment of epilepsy remains a clinical challenge, with> 30% of patients not
responding to current antiseizure drugs (ASDs). Moreover, currently available ASDs are …

Introduction Astrocytes have previously been considered as cells supporting neuronal
functions, but they are now recognized as active players in maintaining central nervous …