Currently, a central question in biology is how signals from the cell surface modulate
intracellular processes. In recent years phosphoinositides have been shown to play a key …

Phosphatidylinositol 3, 4, 5-trisphosphate (PtdInsP3) is rapidly produced upon exposure of
neutrophils to the chemoattractant N-formylmethionyl-leucylphenylalanine (fMLP), and has …

Motility is a complex process that depends on the coordination of many cellular functions,
including the conversion of information from the environment into a series of coordinated …

In mammalian cells, ras genes code for 21-kDa GTP-binding proteins. Increased expression
and mutations in specific amino acids have been closely linked to alterations of normal cell …

Platelet stimulation by thrombin leads to the activation of phosphoinositide 3-kinase (PI 3-K)
and to the production of the D3 phosphoinositides, phosphatidylinositol 3, 4-bisphosphate …

Subcellular gradients of cytosolic free Ca2+ concentration,[Ca2+] i, are thought to be critical
for the localization of functional responses within a cell. A potential but previously …

Profilins are small (12-15 kD), basic proteins that can bind to G-actin under physiological
conditions. Various isoforms have been identified in many different cell types and …

In membranes of myeloid differentiated HL-60 cells, the chemotactic peptide N-formyl-
methionyl-leucyl-phenylalanine stimulates phospholipase C via a pertussis toxin-sensitive G …

Various agonist-induced cell responses in neutrophils and fibroblasts, such as chemotaxis
and cytoskeletal rearrangements, have been shown to correlate with the synthesis of PtdIns …

The shape changes and membrane ruffling that accompany neutrophil activation are
dependent on the assembly and reorganization of the actin cytoskeleton, the molecular …