In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …

Successful cloning of monkeys, the first non-human primate species, by somatic cell nuclear
transfer (SCNT) attracted worldwide attention earlier this year. Remarkably, it has taken …

Generation of genetically uniform non-human primates may help to establish animal models
for primate biology and biomedical research. In this study, we have successfully cloned …

Epigenome reprogramming after fertilization enables transcriptionally quiescent maternal
and paternal chromatin to acquire a permissive state for subsequent zygotic genome …

The oocyte epigenome plays critical roles in mammalian gametogenesis and
embryogenesis. Yet, how it is established remains elusive. Here, we report that histone …

Mammalian oocytes can reprogram somatic cells into a totipotent state enabling animal
cloning through somatic cell nuclear transfer (SCNT). However, the majority of SCNT …

Reprogramming somatic cells into pluripotent embryonic stem cells (ESCs) by somatic cell
nuclear transfer (SCNT) has been envisioned as an approach for generating patient …

Totipotency emerges in early embryogenesis, but its molecular underpinnings remain poorly
characterized. In the present study, we employed DNA fiber analysis to investigate how …

Cell identity is determined by specific gene expression patterns that are conveyed by
interactions between transcription factors and DNA in the context of chromatin. In …

Reprogramming of mouse and human somatic cells can be achieved by ectopic expression
of transcription factors, but with low efficiencies. We report that DNA methyltransferase and …