The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …

The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …

Regulated cell death (RCD) is pivotal in directing the severity and outcome of liver injury.
Hepatocyte cell death is a critical event in the progression of liver disease due to resultant …

Autophagy refers to the process involving the decomposition of intracellular components via
lysosomes. Autophagy plays an important role in maintaining and regulating cell …

Autophagy contributes to the selective degradation of liquid droplets, including the P-
Granule, Ape1-complex and p62/SQSTM1-body, although the molecular mechanisms and …

Macroautophagy is an intracellular degradation system that delivers diverse cytoplasmic
materials to lysosomes via autophagosomes. Recent advances have enabled identification …

Autophagy is a self-eating catabolic pathway that contributes to liver homeostasis through its
role in energy balance and in the quality control of the cytoplasm, by removing misfolded …

The concept of macroautophagy was established in 1963, soon after the discovery of
lysosomes in rat liver. Over the 50 years since, studies of liver autophagy have produced …

Abstract The Nrf2-Keap1-ARE pathway is a redox and xenobiotic sensitive signaling axis
that functions to protect cells against oxidative stress, environmental toxicants, and harmful …

ABSTRACT SQSTM1 (also known as p62) is a multifunctional stress-inducible scaffold
protein involved in diverse cellular processes. Its functions are tightly regulated through an …