An overview of the biophysical applications of atomic force microscopy

NC Santos, MARB Castanho - Biophysical chemistry, 2004 - Elsevier
The potentialities of the atomic force microscopy (AFM) make it a tool of undeniable value for
the study of biologically relevant samples. AFM is progressively becoming a usual benchtop …

Theoretical and computational hierarchical nanomechanics of protein materials: Deformation and fracture

MJ Buehler, S Keten, T Ackbarow - Progress in Materials Science, 2008 - Elsevier
Proteins constitute the building blocks of biological materials such as tendon, bone, skin,
spider silk or cells. An important trait of these materials is that they display highly …

Hierarchies, multiple energy barriers, and robustness govern the fracture mechanics of α-helical and β-sheet protein domains

T Ackbarow, X Chen, S Keten… - Proceedings of the …, 2007 - National Acad Sciences
The fundamental fracture mechanisms of biological protein materials remain largely
unknown, in part, because of a lack of understanding of how individual protein building …

Accelerated mechanochemistry in helical polymers

H Zhang, CE Diesendruck - Angewandte Chemie, 2022 - Wiley Online Library
Polymer chains, if long enough, are known to undergo bond scission when mechanically
stressed. While the mechanochemical response of random coils is well understood …

Chemical modifications of AFM tips for the study of molecular recognition events

R Barattin, N Voyer - Chemical communications, 2008 - pubs.rsc.org
The use of AFM to study molecular recognition events at an incredible level of sensitivity is
currently a very active field of research. In order to get information at the single molecule …

[HTML][HTML] Contribution of hydrophobic interactions to protein mechanical stability

GG Ferenczy, M Kellermayer - Computational and Structural Biotechnology …, 2022 - Elsevier
The role of hydrophobic and polar interactions in providing thermodynamic stability to folded
proteins has been intensively studied, but the relative contribution of these interactions to the …

Coiled-coil nanomechanics and uncoiling and unfolding of the superhelix and α-helices of myosin

DD Root, VK Yadavalli, JG Forbes, K Wang - Biophysical journal, 2006 - cell.com
The nanomechanical properties of the coiled-coils of myosin are fundamentally important in
understanding muscle assembly and contraction. Force spectra of single molecules of …

Alpha-helical protein networks are self-protective and flaw-tolerant

T Ackbarow, D Sen, C Thaulow, MJ Buehler - PLoS One, 2009 - journals.plos.org
Alpha-helix based protein networks as they appear in intermediate filaments in the cell's
cytoskeleton and the nuclear membrane robustly withstand large deformation of up to …

Secondary structure-governed polypeptide cross-linked polymeric hydrogels

C Chen, J Lan, Y Li, D Liang, X Ni, Q Liu - Chemistry of Materials, 2019 - ACS Publications
Modulation of the secondary structures of peptides gives rise to a range of natural peptide-
based soft materials with outstanding mechanical properties. Here, we discuss detailed …

pH triggered release of protective poly (ethylene glycol)-b-polycation copolymers from liposomes

DT Auguste, SP Armes, KR Brzezinska, TJ Deming… - Biomaterials, 2006 - Elsevier
Triggered release of adsorbed polymers from liposomes enables protection against immune
recognition during circulation and subsequent intracellular delivery of DNA. Polycationic …