Unique functional responses differentially map onto genetic subtypes of dopamine neurons

M Azcorra, Z Gaertner, C Davidson, Q He, H Kim… - Nature …, 2023 - nature.com
Dopamine neurons are characterized by their response to unexpected rewards, but they
also fire during movement and aversive stimuli. Dopamine neuron diversity has been …

[HTML][HTML] The proteomic landscape of synaptic diversity across brain regions and cell types

M van Oostrum, TM Blok, SL Giandomenico… - Cell, 2023 - cell.com
Neurons build synaptic contacts using different protein combinations that define the
specificity, function, and plasticity potential of synapses; however, the diversity of synaptic …

Advances and opportunities in methods to study protein translation-A review

D Zhang, Y Gao, L Zhu, Y Wang, P Li - International Journal of Biological …, 2024 - Elsevier
It is generally believed that the regulation of gene expression involves protein translation
occurring before RNA transcription. Therefore, it is crucial to investigate protein translation …

The brain's dark transcriptome: Sequencing RNA in distal compartments of neurons and glia

SA Ament, A Poulopoulos - Current opinion in neurobiology, 2023 - Elsevier
Transcriptomic approaches are powerful strategies to map the molecular diversity of cells in
the brain. Single-cell genomic atlases have now been compiled for entire mammalian …

A synaptomic analysis reveals dopamine hub synapses in the mouse striatum

V Paget-Blanc, ME Pfeffer, M Pronot, P Lapios… - Nature …, 2022 - nature.com
Dopamine transmission is involved in reward processing and motor control, and its
impairment plays a central role in numerous neurological disorders. Despite its strong …

Subcellular proteomics of dopamine neurons in the mouse brain

BD Hobson, SJ Choi, EV Mosharov, RK Soni, D Sulzer… - Elife, 2022 - elifesciences.org
Dopaminergic neurons modulate neural circuits and behaviors via dopamine (DA) release
from expansive, long range axonal projections. The elaborate cytoarchitecture of these …

Methodological concerns and lack of evidence for single-synapse RNA-seq

BD Hobson, E Herzog - Nature Biotechnology, 2023 - nature.com
In a recent issue of Nature Biotechnology, Niu et al. 1 develop a new droplet-based RNA
sequencing (RNA-seq) method and apply it to particles derived from subcellular …

Adaptation to photoperiod via dynamic neurotransmitter segregation

G Maddaloni, YJ Chang, RA Senft, SM Dymecki - Nature, 2024 - nature.com
Abstract Changes in the amount of daylight (photoperiod) alter physiology and behaviour,.
Adaptive responses to seasonal photoperiods are vital to all organisms—dysregulation …

[HTML][HTML] Polarity-dependent expression and localization of secretory glucoamylase mRNA in filamentous fungal cells

Y Morita, K Takegawa, BM Collins, Y Higuchi - Microbiological Research, 2024 - Elsevier
In multinuclear and multicellular filamentous fungi little is known about how mRNAs
encoding secreted enzymes are transcribed and localized spatiotemporally. To better …

Association of protein distribution and gene expression revealed by positron emission tomography and postmortem gene expression in the dopaminergic system of …

Y Yamamoto, K Takahata, M Kubota… - European Journal of …, 2023 - Springer
Purpose The topological distribution of dopamine-related proteins is determined by gene
transcription and subsequent regulations. Recent research strategies integrating positron …