Inherited mutations in the rod visual pigment, rhodopsin, cause the degenerative blinding
condition, retinitis pigmentosa (RP). Over 150 different mutations in rhodopsin have been …

Protein folding is a complex, error-prone process that often results in an irreparable protein
by-product. These by-products can be recognized by cellular quality control machineries …

Misfolded proteins compromise cellular homeostasis. This is especially problematic in the
endoplasmic reticulum (ER), which is a high-capacity protein-folding compartment and …

Retinal degenerations are a group of clinically and genetically heterogeneous disorders
characterised by progressive loss of vision due to neurodegeneration. The retina is a highly …

Mutations in rhodopsin, the light-sensitive protein of rod cells, are the most common cause of
dominant retinitis pigmentosa (RP), a type of inherited blindness caused by the dysfunction …

Gene therapy for dominantly inherited genetic disease is more difficult than gene-based
therapy for recessive disorders, which can be treated with gene supplementation. Treatment …

Alphaviruses are a large class of insect-borne human pathogens and little is known about
the host-factor requirements for infection. To identify such factors, we performed a genome …

Autophagy is a critical metabolic process that acts as a major self-digestion and recycling
pathway contributing to maintain cellular homeostasis. An emerging field of research …

The most common Rhodopsin (Rh) mutation associated with autosomal dominant retinitis
pigmentosa (ADRP) in North America is the substitution of proline 23 by histidine (RhP23H) …

The majority of mutations in rhodopsin (RHO) cause misfolding of the protein and has been
linked to degeneration of photoreceptor cells in the retina. A lot of attention has been set on …