Self-assembled peptide and protein nanostructures for anti-cancer therapy: Targeted delivery, stimuli-responsive devices and immunotherapy
Self-assembled peptides and proteins possess tremendous potential as targeted drug
delivery systems and key applications of these well-defined nanostructures reside in anti …
delivery systems and key applications of these well-defined nanostructures reside in anti …
Harnessing the immune system against cancer: current immunotherapy approaches and therapeutic targets
Cancer immunotherapy is a rapidly evolving concept that has been given the tag" fifth pillar"
of cancer therapy while radiation therapy, chemotherapy, surgery and targeted therapy …
of cancer therapy while radiation therapy, chemotherapy, surgery and targeted therapy …
[HTML][HTML] Extracellular heat shock proteins and cancer: New perspectives
Heat shock proteins (HSPs) are a large family of molecular chaperones aberrantly
expressed in cancer. The expression of HSPs in tumor cells has been shown to be …
expressed in cancer. The expression of HSPs in tumor cells has been shown to be …
J-domain protein chaperone circuits in proteostasis and disease
The J-domain proteins (JDP) form the largest protein family among cellular chaperones. In
cooperation with the Hsp70 chaperone system, these co-chaperones orchestrate a plethora …
cooperation with the Hsp70 chaperone system, these co-chaperones orchestrate a plethora …
Plasma HSP90AA1 predicts the risk of breast cancer onset and distant metastasis
H Liu, Z Zhang, Y Huang, W Wei, S Ning, J Li… - Frontiers in Cell and …, 2021 - frontiersin.org
Aim We aimed to develop and validate a comprehensive nomogram containing pre-
treatment plasma HSP90AA1 to predict the risk of breast cancer onset and metastasis …
treatment plasma HSP90AA1 to predict the risk of breast cancer onset and metastasis …
The role of heat shock proteins in metastatic colorectal cancer: A review
Heat shock proteins (HSPs) are a large molecular chaperone family classified by their
molecular weights, including HSP27, HSP40, HSP60, HSP70, HSP90, and HSP110. HSPs …
molecular weights, including HSP27, HSP40, HSP60, HSP70, HSP90, and HSP110. HSPs …
Heat shock proteins are essential components in transformation and tumor progression: cancer cell intrinsic pathways and beyond
BJ Lang, ME Guerrero-Giménez, TL Prince… - International journal of …, 2019 - mdpi.com
Heat shock protein (HSP) synthesis is switched on in a remarkably wide range of tumor
cells, in both experimental animal systems and in human cancer, in which these proteins …
cells, in both experimental animal systems and in human cancer, in which these proteins …
The TRiCky business of protein folding in health and disease
H Ghozlan, A Cox, D Nierenberg, S King… - Frontiers in Cell and …, 2022 - frontiersin.org
Maintenance of the cellular proteome or proteostasis is an essential process that when
deregulated leads to diseases like neurological disorders and cancer. Central to …
deregulated leads to diseases like neurological disorders and cancer. Central to …
Human surfactant protein SP-A1 and SP-A2 variants differentially affect the alveolar microenvironment, surfactant structure, regulation and function of the alveolar …
J Floros, N Thorenoor, N Tsotakos… - Frontiers in …, 2021 - frontiersin.org
The human innate host defense molecules, SP-A1 and SP-A2 variants, differentially affect
survival after infection in mice and in lung transplant patients. SP-A interacts with the …
survival after infection in mice and in lung transplant patients. SP-A interacts with the …
Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis
AE Showalter, AC Martini, D Nierenberg, K Hosang… - Scientific reports, 2020 - nature.com
Abstract Chaperonin-containing TCP-1 (CCT or TRiC) is a multi-subunit complex that folds
many of the proteins essential for cancer development. CCT is expressed in diverse cancers …
many of the proteins essential for cancer development. CCT is expressed in diverse cancers …