Navigating Available Treatment Options for Carbapenem-Resistant Acinetobacter baumannii-calcoaceticus Complex Infections

RK Shields, DL Paterson… - Clinical Infectious …, 2023 - academic.oup.com
Carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex (CRAB) is one of
the top-priority pathogens for new antibiotic development. Unlike other antibiotic-resistant …

Sulbactam‐durlobactam: A novel β‐lactam‐β‐lactamase inhibitor combination targeting carbapenem‐resistant Acinetobacter baumannii infections

A El‐Ghali, AJ Kunz Coyne, K Caniff… - … : The Journal of …, 2023 - Wiley Online Library
Carbapenem‐resistant Acinetobacter baumannii (CRAB) is a difficult‐to‐treat nosocomial
pathogen responsible for significant morbidity and mortality. Sulbactam‐durlobactam (SUL …

Eravacycline, the first four years: Health outcomes and tolerability data for 19 hospitals in 5 US regions from 2018 to 2022

AJ Kunz Coyne, S Alosaimy, K Lucas… - Microbiology …, 2024 - Am Soc Microbiol
Eravacycline is a synthetic fluorocycline approved by the US Food and Drug Administration
in 2018. This study aimed to describe clinical and microbiological outcomes in addition to …

Salvage therapy with sulbactam/durlobactam against cefiderocol-resistant Acinetobacter baumannii in a critically ill burn patient: clinical challenges and molecular …

G Tiseo, C Giordano, A Leonildi… - JAC-Antimicrobial …, 2023 - academic.oup.com
Abstract Background Carbapenem-resistant Acinetobacter baumannii (CRAB) infections are
associated with high mortality rates. The optimal treatment regimen for CRAB has not been …

Antibiotic Treatment of Carbapenem-Resistant Acinetobacter baumannii Infections in View of the Newly Developed β-Lactams: A Narrative Review of the Existing …

F Serapide, M Guastalegname, SP Gullì, R Lionello… - Antibiotics, 2024 - mdpi.com
It is estimated that antimicrobial resistance (AMR) is responsible for nearly 5 million human
deaths worldwide each year and will reach 10 million by 2050. Carbapenem-resistant …

In Vivo Emergence of Pandrug-Resistant Acinetobacter baumannii Strain: Comprehensive Resistance Characterization and Compassionate Use of Sulbactam …

M VanNatta, L Grier, MH Khan… - Open Forum …, 2023 - academic.oup.com
The treatment of patients with infection secondary to carbapenem-resistant Acinetobacter
baumannii with emerging cefiderocol resistance remains challenging and unclear. We …

Novel agents in development for the treatment of resistant Gram-negative infections

M Bassetti, B Larosa, A Vena… - Expert Review of Anti …, 2024 - Taylor & Francis
Introduction Several novel agents are in advanced stages of clinical development,
potentially expanding our treatment options against third-and fourth-generation …

The challenges of difficult-to-treat Acinetobacter infections

GA Richards, O Perovic, AJ Brink - Clinical Microbiology Reviews, 2024 - journals.asm.org
Infections due to Acinetobacter spp. are among the most difficult to treat. Most are resistant to
standard antibiotics, and there is difficulty in distinguishing colonizers from pathogens. This …

Cefiderocol and Sulbactam-Durlobactam against Carbapenem-Resistant Acinetobacter baumannii

A Karruli, A Migliaccio, S Pournaras… - Antibiotics, 2023 - mdpi.com
Infections caused by carbapenem-resistant Acinetobacter baumannii (CRAB) remain a
clinical challenge due to limited treatment options. Recently, cefiderocol, a novel …

Potentially effective antimicrobial treatment for pneumonia caused by isolates of carbapenem-resistant and extensively drug-resistant Acinetobacter baumannii …

SS Jean, CY Liu, TY Huang, CC Lai, IM Liu… - Expert Review of Anti …, 2024 - Taylor & Francis
ABSTRACT Introduction Acinetobacter baumannii complex (Abc) is currently a significant
cause of difficult-to-treat pneumonia. Due to the high prevalence rates of carbapenem-and …