The lipid-lowering drugs, 3-hydroxy-3-methylgulutaryl-coenzyme A (HMG-CoA) reductase
inhibitors or statins, are used in the prevention and treatment of cardiovascular diseases …

Statins inhibit 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase, the rate-
limiting enzyme in cholesterol biosynthesis, which converts HMG-CoA to mevalonate …

The regulation of sympathetic nerve activity in chronic heart failure (CHF) has been an area
of renewed investigation. Understanding the central mechanisms that are responsible for …

Inhibitors of HMG-CoA reductase (statins) are potent cholesterol-lowering drugs. Large
clinical trials have shown that statins reduce the incidence of cerebrovascular events, which …

receptor antisense oligonucleotide administration into the cerebral ventricles reduced
baseline sympathetic nerve activity in rats with CHF while having no effect in normal rats. 36 …

Nitric oxide (NO) and reactive oxygen species (ROS) play important roles in blood pressure
regulation via the modulation of the autonomic nervous system, particularly in the central …

The sympathetic nervous system plays a critical role in the pathogenesis of hypertension.
The central nervous system (CNS) organizes the sympathetic outflow and various inputs …

HIROOKA Y et al. rats. In addition, superoxide dismutase (SOD) expression and activity,
which are ROS scavenging factors, were decreased in the RVLM of SHRSP compared with …

The pathogenesis of hypertension and its mode of progression are complex, multifactoral
and incompletely understood. However, there is accumulating evidence from humans and …

Neuronal nitric oxide synthase (nNOS) is a key enzyme for nitric oxide production in
neuronal tissues and contributes to the spinal central sensitization in inflammatory pain …