Epithelial tight junctions define the paracellular permeability of the intestinal barrier.
Molecules can cross the tight junctions via two distinct size-selective and charge-selective …

Abstract Magnesium (Mg 2+) is an essential ion to the human body, playing an instrumental
role in supporting and sustaining health and life. As the second most abundant intracellular …

Claudins are tight junction membrane proteins that are expressed in epithelia and
endothelia and form paracellular barriers and pores that determine tight junction …

Understanding of tight junctions has evolved from their historical perception as inert solute
barriers to recognition of their physiological and biochemical complexity. Many proteins are …

Traumatic brain injury (TBI) remains a significant source of death and permanent disability,
contributing to nearly one-third of all injury related deaths in the United States and exacting …

The tight junction forms a barrier against unlimited paracellular passage but some of the
tight junction proteins just do the opposite, they form extracellular channels zigzagging …

Epithelial transport relies on the proper function and regulation of the tight junction (TJ),
other‐wise uncontrolled paracellular leakage of solutes and water would occur. They also …

Claudins are tetraspan transmembrane proteins of tight junctions. They determine the
barrier properties of this type of cell–cell contact existing between the plasma membranes of …

▪ Abstract Tight junctions form continuous intercellular contacts controlling solute movement
through the paracellular pathway across epithelia. Paracellular barriers vary among …

Tight junctions create a paracellular barrier in epithelial and endothelial cells protecting
them from the external environment. Two different classes of integral membrane proteins …