Phospholipid scramblase 1: a protein with multiple functions via multiple molecular interactors

J Dal Col, MJ Lamberti, A Nigro, V Casolaro… - Cell Communication and …, 2022 - Springer
Abstract Phospholipid scramblase 1 (PLSCR1) is the most studied protein of the scramblase
family. Originally, it was identified as a membrane protein involved in maintaining plasma …

Multifaced roles of PLAC8 in cancer

M Mao, Y Cheng, J Yang, Y Chen, L Xu, X Zhang… - Biomarker …, 2021 - Springer
The role of PLAC8 in tumorigenesis has been gradually elucidated with the development of
research. Although there are common molecular mechanisms that enforce cell growth, the …

PLAC8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration

WL Chang, YW Liu, YL Dang, XX Jiang, H Xu… - …, 2018 - journals.biologists.com
Proper differentiation of trophoblast cells in the human placenta is a prerequisite for a
successful pregnancy, and dysregulation of this process may lead to malignant pregnancy …

Plac8 is an inducer of C/EBPβ required for brown fat differentiation, thermoregulation, and control of body weight

M Jimenez-Preitner, X Berney, M Uldry, A Vitali, S Cinti… - Cell metabolism, 2011 - cell.com
Brown adipocytes oxidize fatty acids to produce heat in response to cold or to excessive
energy intake; stimulation of brown fat development and function may thus counteract …

Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression

C Kinsey, V Balakrishnan, MR O'Dell, JL Huang… - Cell reports, 2014 - cell.com
Mutations in p53 and RAS potently cooperate in oncogenic transformation, and
correspondingly, these genetic alterations frequently coexist in pancreatic ductal …

PLAC8 localizes to the inner plasma membrane of pancreatic cancer cells and regulates cell growth and disease progression through critical cell-cycle regulatory …

BP Kaistha, H Lorenz, H Schmidt, B Sipos, M Pawlak… - Cancer research, 2016 - AACR
Pancreatic ductal adenocarcinoma (PDAC) carries the most dismal prognosis of all solid
tumors and is generally strongly resistant to currently available chemo-and/or radiotherapy …

The novel KLF4/PLAC8 signaling pathway regulates lung cancer growth

Y Jia, X Ying, J Zhou, Y Chen, X Luo, S Xie… - Cell death & …, 2018 - nature.com
Accumulating evidence suggests that placenta-specific 8 (PLAC8) plays an important role in
normal cellular process and human diseases, including multiple types of human tumors, and …

Let-7b expression determines response to chemotherapy through the regulation of cyclin D1 in glioblastoma

Y Guo, K Yan, J Fang, Q Qu, M Zhou… - Journal of Experimental & …, 2013 - Springer
Background Glioblastoma is the most common type of primary brain tumors. Cisplatin is a
commonly used chemotherapeutic agent for Glioblastoma patients. Despite a consistent rate …

Plac8-dependent and inducible NO synthase-dependent mechanisms clear Chlamydia muridarum infections from the genital tract

RM Johnson, MS Kerr, JE Slaven - The Journal of Immunology, 2012 - journals.aai.org
Chlamydia trachomatis urogenital serovars replicate predominantly in genital tract
epithelium. This tissue tropism poses a unique challenge for host defense and vaccine …

Transcriptome Display During Testicular Differentiation of Channel Catfish (Ictalurus punctatus) as Revealed by RNA-Seq Analysis

Q Zeng, S Liu, J Yao, Y Zhang, Z Yuan… - Biology of …, 2016 - academic.oup.com
Channel catfish (Ictalurus punctatus) has been recognized as a dominant freshwater
aquaculture species in the United States. It is also a suitable model for studying the …