Macromolecular crowding effects on protein dynamics

N Das, T Khan, B Halder, S Ghosh, P Sen - International Journal of …, 2024 - Elsevier
Macromolecular crowding experiments bridge the gap between in-vivo and in-vitro studies
by mimicking some of the cellular complexities like high viscosity and limited space, while …

Role of Associated Water Dynamics on Protein Stability and Activity in Crowded Milieu

T Khan, B Halder, N Das, P Sen - The Journal of Physical …, 2024 - ACS Publications
Macromolecular crowding bridges in vivo and in vitro studies by simulating cellular
complexities such as high viscosity and limited space while maintaining the experimental …

Harnessing solvation-guided engineering to enhance deep eutectic solvent resistance and thermostability in enzymes

Y Sheng, H Cui, X Wang, M Wang, P Song… - Green …, 2024 - pubs.rsc.org
Deep eutectic solvents (DESs) are gaining rapid prominence in numerous biocatalysis
processes due to their green characteristics, biodegradability, low cost, and simple …

Ultrafast Intersystem Crossing in Benzanthrone: Effect of Hydrogen Bonding and Viscosity

S Bhowmik, A Dutta, P Sen - The Journal of Physical Chemistry A, 2024 - ACS Publications
Understanding the intricate factors governing intersystem crossing (ISC) in aromatic
carbonyl compounds remains a long-standing interest among researchers. This study …

Osmolyte induced protein stabilization: modulation of associated water dynamics might be a key factor

KS Negi, N Das, T Khan, P Sen - Physical Chemistry Chemical Physics, 2023 - pubs.rsc.org
The mechanism of protein stabilization by osmolytes remains one of the most important and
long-standing puzzles. The traditional explanation of osmolyte-induced stability through the …

Oleylammonium fluoride passivated blue-emitting 2D CsPbBr 3 nanoplates with near-unity photoluminescence quantum yield: safeguarding against threats from …

A Sen, A Dutta, AL Bose, P Sen - Chemical Science, 2025 - pubs.rsc.org
Quantum-confined, two-dimensional (2D) CsPbBr3 (CPB) nanoplates (NPLs) have emerged
as exceptional candidates for next-generation blue LEDs and display technology …

Critical Role of Water beyond the Media to Maintain Protein Stability and Activity in Hydrated Deep Eutectic Solvent

T Khan, N Das, S Bhowmik, KS Negi… - The Journal of Physical …, 2024 - ACS Publications
Hydrated deep eutectic solvents (DESs) are recognized for their potential in biocatalysis due
to their tunability, biocompatibility, greenness, and ability to keep protein stable and active …

[HTML][HTML] Exploration of semi-carbazone derivatives as promising agents against cholera: Insights from spectroscopic analysis, reactivity studies (ELF, HOMO-LUMO …

AE Owen, IA Anyambula, CU Benson, FO Ojumola… - Chemical Physics …, 2024 - Elsevier
This study is aimed at evaluating the impact of solvation on the structural, spectroscopy (UV,
NMR, FT-IR), reactivity, bonding interactions, and the drug potential of Pyridine 4 …

The shift of excitation spectra at blue edge of emission (BEEmS) as a new methodology to probe heterogeneity

N Das, T Khan, P Sen - Chemical Physics, 2024 - Elsevier
Many current methods for detecting molecular-level heterogeneity are complex and require
stringent data analysis, limiting their widespread use. Herein, we propose a novel edge …

Tracking heterogenous protein aggregation at nanoscale through fluorescence correlation spectroscopy

B Halder, S Ghosh, T Khan, S Pal… - Photochemistry and …, 2024 - Wiley Online Library
Various biophysical techniques have been extensively employed to study protein
aggregation due to its significance. Traditionally, these methods detect aggregation at …