Multiple myeloma (MM, plasma cell myeloma) is a malignant hematologic disease
characterized by the clonal proliferation of malignant plasma cells. The treatment of MM has …

DNA helicases, known for their fundamentally important roles in genomic stability, are high
profile players in cancer. Not only are there monogenic helicase disorders with a strong …

DNA inter-strand crosslinks (ICLs) are dangerous lesions that can be caused by a variety of
endogenous and exogenous bifunctional compounds. Because covalently linking both …

RECQ1 (also known as RECQL or RECQL1) belongs to the RecQ family of DNA helicases,
members of which are linked with rare genetic diseases of cancer predisposition in humans …

Unmethylated cytosine-phosphorothioate-guanine (CpG)-containing oligodeoxynucleotides
(ODNs) are synthetic DNA sequences that mimic bacterial DNA, and are known to serve as …

The response of cancer cells to therapeutic drugs that cause DNA damage depends on
genes playing a role in DNA repair. RecQ-like helicase 1 (RECQ1), a DNA repair helicase …

Simple Summary Multiple myeloma is a hematologic cancer characterized by the
accumulation of malignant plasma cells in the bone marrow. It remains a mostly incurable …

Stem cells, as a group of undifferentiated cells, are enriched with self-renewal and high
proliferative capacity, which have attracted the attention of many researchers as a promising …

Diepoxybutane (DEB) is the most potent active metabolite of the environmental chemical 1,
3‐butadiene (BD). BD is a human carcinogen that exhibits multiorgan systems toxicity. Our …

RECQL4, one of three diseased-linked RecQ helicases in humans, is an important caretaker
of genome stability. However, technical challenges associated with RECQL4 have limited …