An inflammation-centric view of neurological disease: beyond the neuron
Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …
The ST2/IL-33 axis in immune cells during inflammatory diseases
B Griesenauer, S Paczesny - Frontiers in immunology, 2017 - frontiersin.org
Il1rl1 (also known as ST2) is a member of the IL-1 superfamily, and its only known ligand is
IL-33. ST2 exists in two forms as splice variants: a soluble form (sST2), which acts as a …
IL-33. ST2 exists in two forms as splice variants: a soluble form (sST2), which acts as a …
Functional immune cell–astrocyte interactions
Astrocytes are abundant glial cells in the central nervous system (CNS) that control multiple
aspects of health and disease. Through their interactions with components of the blood …
aspects of health and disease. Through their interactions with components of the blood …
The IL-1 family cytokines and receptors in autoimmune diseases
P Migliorini, P Italiani, F Pratesi, I Puxeddu… - Autoimmunity …, 2020 - Elsevier
The role of the cytokines and receptors of the IL-1 family in inflammation is well known.
Several cytokines of the family have a powerful inflammatory activity, with IL-1β being the …
Several cytokines of the family have a powerful inflammatory activity, with IL-1β being the …
IL-33/ST2 axis in autoimmune disease
L Shakerian, H Kolahdooz, M Garousi, V Keyvani… - Cytokine, 2022 - Elsevier
Abstract Interleukin-33 (IL-33) is a member of the IL-1 family and plays an ambivalent role in
autoimmune diseases. IL-33 signals via the ST2 receptor and drives cytokine production in …
autoimmune diseases. IL-33 signals via the ST2 receptor and drives cytokine production in …
Conflicting vascular and metabolic impact of the IL-33/sST2 axis
Abstract Interleukin 33 (IL-33), which is expressed by several immune cell types, endothelial
and epithelial cells, and fibroblasts, is a cytokine of the IL-1 family that acts both intra-and …
and epithelial cells, and fibroblasts, is a cytokine of the IL-1 family that acts both intra-and …
IL-1 family cytokines trigger sterile inflammatory disease
JR Lukens, JM Gross, TD Kanneganti - Frontiers in immunology, 2012 - frontiersin.org
Inflammation plays vital roles in protective responses against pathogens and tissue repair,
however, improper resolution of inflammatory networks is centrally involved in the …
however, improper resolution of inflammatory networks is centrally involved in the …
Pleiotropic Effects of IL-33 on CD4+ T Cell Differentiation and Effector Functions
F Alvarez, JH Fritz, CA Piccirillo - Frontiers in immunology, 2019 - frontiersin.org
IL-33, a member of the IL-1 family of cytokines, was originally described in 2005 as a
promoter of type 2 immune responses. However, recent evidence reveals a more complex …
promoter of type 2 immune responses. However, recent evidence reveals a more complex …
Dual roles of interleukin-33 in cognitive function by regulating central nervous system inflammation
X Rao, F Hua, L Zhang, Y Lin, P Fang, S Chen… - Journal of Translational …, 2022 - Springer
With the advent of an aging society, the incidence of dementia is increasing, resulting in a
vast burden on society. It is increasingly acknowledged that neuroinflammation is implicated …
vast burden on society. It is increasingly acknowledged that neuroinflammation is implicated …
Neuroinflammation, mast cells, and glia: dangerous liaisons
The perspective of neuroinflammation as an epiphenomenon following neuron damage is
being replaced by the awareness of glia and their importance in neural functions and …
being replaced by the awareness of glia and their importance in neural functions and …