Alzheimer disease (AD) is characterized by progressive cognitive decline in older
individuals accompanied by the presence of two pathological protein aggregates—amyloid …

Paired helical filaments (PHFs) from the Alzheimer's disease (AD) brain are highly
ubiquitinated and ubiquitination likely plays a vital role in tau filament formation. Whether tau …

The aggregation and prion-like propagation of α-synuclein are involved in the pathogenesis
of Parkinson's disease. However, the underlying mechanisms regulating the assembly and …

Tau aggregation into amyloid fibers based on the cross-beta structure is a hallmark of
several Tauopathies, including Alzheimer Disease (AD). Trans-cellular propagation of Tau …

Neurofilament and tau proteins are neuron-specific cytoskeletal proteins that are enriched in
axons, regulated by many of the same protein kinases, interact physically, and are the …

Neurodegenerative disorders are characterized by neuronal loss, usually in late life. But
recently, abnormalities of proteins implicated in neurodegenerative disorders have been …

Alzheimer's disease (AD) is one of the neurodegenerative brain disorders inducing nearly
half of dementia cases, and the diagnosis and treatment of AD are the primary issues …

Compartmentalized microfluidic neural cell culture platforms, which physically separate
axons from the neural soma using a series of microchannels, have been used for studying a …

Accumulation of pathological tau in synapses has been identified as an early event in
Alzheimer's disease (AD) and correlates with cognitive decline in patients with AD. Tau is a …

Accumulation of phosphorylated tau (p-tau) has long been an underappreciated hallmark of
Alzheimer's disease. Tau is one of the major components of microtubule networks in …