Mitochondrial retrograde signaling is a pathway of communication from mitochondria to the
nucleus that influences many cellular and organismal activities under both normal and …

Mitochondrial retrograde signaling is a pathway of communication from mitochondria to the
nucleus under normal and pathophysiological conditions. The best understood of such …

INTRODUCTION Mitochondria provide cells with energy and numerous essential
metabolites such as lipids, amino acids, iron sulfur clusters, and heme. All mitochondrial …

Upon disturbance of their function by stress, mitochondria can signal to the nucleus to steer
the expression of responsive genes. This mitochondria-to-nucleus communication is often …

The increased incidence of invasive mycoses and the emerging problem of antifungal drug
resistance has prompted investigations of the underlying molecular mechanisms …

The longstanding model is that most bloodstream infections (BSIs) are caused by a single
organism. We perform whole genome sequencing of five-to-ten strains from blood culture …

Much progress has been made in the last decade in identifying genes responsible for
antifungal resistance in Candida albicans. Attention has focused on five major C. albicans …

Mitochondrial fidelity is a key determinant of longevity and was found to be perturbed in a
multitude of disease contexts ranging from neurodegeneration to heart failure. Tight …

Candida glabrata, a yeast with intrinsically low susceptibility to azoles, frequently develops
increased azole resistance during prolonged treatment. Transposon mutagenesis revealed …

Recently, mitochondria have been identified as important contributors to the virulence and
drug tolerance of human fungal pathogens. In different scenarios, either hypo-or …