Language models generalize beyond natural proteins
Learning the design patterns of proteins from sequences across evolution may have
promise toward generative protein design. However it is unknown whether language …
promise toward generative protein design. However it is unknown whether language …
Chitosan molecular structure as a function of N‐acetylation
Molecular dynamics simulations have been carried out to characterize the structure and
solubility of chitosan nanoparticle‐like structures as a function of the deacetylation level (0 …
solubility of chitosan nanoparticle‐like structures as a function of the deacetylation level (0 …
A circuit node that integrates convergent input from neuromodulatory and social behavior-promoting neurons to control aggression in Drosophila
Diffuse neuromodulatory systems such as norepinephrine (NE) control brain-wide states
such as arousal, but whether they control complex social behaviors more specifically is not …
such as arousal, but whether they control complex social behaviors more specifically is not …
Rosetta FunFolDes–A general framework for the computational design of functional proteins
The robust computational design of functional proteins has the potential to deeply impact
translational research and broaden our understanding of the determinants of protein …
translational research and broaden our understanding of the determinants of protein …
Atomic molecular dynamics simulation advances of de novo-designed proteins
M Wang, A Ma, H Wang, X Lou - Quarterly Reviews of Biophysics, 2024 - cambridge.org
Proteins are vital biological macromolecules that execute biological functions and form the
core of synthetic biological systems. The history of de novo protein has evolved from initial …
core of synthetic biological systems. The history of de novo protein has evolved from initial …
Coordinate-Dependent Drift-Diffusion Reveals the Kinetic Intermediate Traps of Top7-Based Proteins
RJ Oliveira - The Journal of Physical Chemistry B, 2022 - ACS Publications
The computer-designed Top7 served as a scaffold to produce immunoreactive proteins by
grafting of the 2F5 HIV-1 antibody epitope (Top7–2F5) followed by biotinylation (Top7–2F5 …
grafting of the 2F5 HIV-1 antibody epitope (Top7–2F5) followed by biotinylation (Top7–2F5 …
Probing the stability-limiting regions of an antibody single-chain variable fragment: a molecular dynamics simulation study
T Wang, Y Duan - Protein Engineering, Design & Selection, 2011 - academic.oup.com
Antibody single-chain variable fragments (scFvs) offer particular advantages over the full-
size antibodies, including easy expression, efficient local concentration and fast body …
size antibodies, including easy expression, efficient local concentration and fast body …
Synthesis, characterization and biocompatibility of a multifunctional gold nanoparticle system for the delivery of single-stranded RNA to lymphocytes
The use of RNA macromolecules as therapeutic agents for HIV and other infectious
diseases is promising but limited by suboptimal delivery to the target site. With HIV infection …
diseases is promising but limited by suboptimal delivery to the target site. With HIV infection …
Aptamers as affinity reagents in an integrated electrophoretic lab-on-a-chip platform
AH Hecht, GJ Sommer, RH Durland, X Yang… - Analytical …, 2010 - ACS Publications
Nucleic acid based affinity reagents (eg, aptamers) offer several possible advantages over
antibodies as specific recognition elements in biochemical assays. Besides offering …
antibodies as specific recognition elements in biochemical assays. Besides offering …
De novo design of immunoreactive conformation-specific HIV-1 epitopes based on Top7 scaffold
Epitope exposure strategies often fail due to high conformational instability, resulting in loss
of native conformation and fast degradation. Protein scaffolding, where a structural element …
of native conformation and fast degradation. Protein scaffolding, where a structural element …