Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC)
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …

Transient Receptor Potential (TRP) channels are multifunctional sensory molecules that are
abundant in the skin and are involved in the sensory pathways of itch, pain, and …

Chronic neurohormonal and mechanical stresses are central features of heart disease.
Increasing evidence supports a role for the transient receptor potential canonical channels …

The old Greek aphorism 'Panta Rhei'('everything flows') is true for all living things in general.
As a dynamic process, calcium signaling plays fundamental roles in cellular activities under …

The major function of the lymphatic system is to drain interstitial fluid from tissue. Functional
drainage causes increased fluid flow that triggers lymphatic expansion, which is …

Autophagy is a cellular process in which the cell degrades and recycles its own constituents.
Given the crucial role of autophagy in physiology, deregulation of autophagic machinery is …

One question in lymphocyte homing is how integrins are rapidly activated to enable
immediate arrest of fast rolling lymphocytes upon encountering chemokines at target …

Aberrant Ca2+ release-activated Ca2+ (CRAC) channel activity has been implicated in a
number of human disorders, including immunodeficiency, autoimmunity, occlusive vascular …