The host response to viruses includes multiple cell types that have regulatory function. Most
information focuses on CD 4+ regulatory T cells that express the transcription factor Foxp3+ …

Regulatory T cells (Tregs) constitute a fascinating subpopulation of CD4+ T cells due to their
ability to limit the immune response against self and non-self antigens. Murine models and …

Mucosal Th17 cells play an important role in maintaining gut epithelium integrity and thus
prevent microbial translocation. Chronic HIV infection is characterized by mucosal Th17 cell …

Natural regulatory T cells (Tregs) participate in responses to various chronic infections
including HIV. HIV infection is associated with a progressive CD4 lymphopenia and …

Nonhuman primate natural hosts for simian immunodeficiency viruses (SIV) develop a
nonresolving chronic infection but do not develop AIDS. Mechanisms to explain the …

We explored the gut microbiota profile among HIV-infected individuals with diverse immune
recovery profiles following long-term suppressive ART and investigated the relationship …

The study of individuals at opposite ends of the HIV clinical spectrum can provide invaluable
insights into HIV biology. Heterogeneity in criteria used to define these individuals can …

Highly active antiretroviral therapy (ART) can effectively inhibit virus replication and restore
immune function in most people living with human immunodeficiency virus (HIV). However …

T regulatory cells (Tregs) are a key component of the immune system, which maintain a
delicate balance between overactive responses and immunosuppression. As such, Treg …

Background HIV infection promotes the expansion of immunosuppressive regulatory T-cells
(Tregs), contributing to immune dysfunction, tissue fibrosis and disease progression. Early …