Drug resistance in epilepsy: clinical impact, potential mechanisms, and new innovative treatment options

W Löscher, H Potschka, SM Sisodiya, A Vezzani - Pharmacological reviews, 2020 - ASPET
Epilepsy is a chronic neurologic disorder that affects over 70 million people worldwide.
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …

Neuronal hyperexcitability in Alzheimer's disease: what are the drivers behind this aberrant phenotype?

H Targa Dias Anastacio, N Matosin, L Ooi - Translational psychiatry, 2022 - nature.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder leading to loss of
cognitive abilities and ultimately, death. With no cure available, limited treatments mostly …

Developmental and epileptic encephalopathies: what we do and do not know

N Specchio, P Curatolo - Brain, 2021 - academic.oup.com
Developmental encephalopathies, including intellectual disability and autistic spectrum
disorder, are frequently associated with infant epilepsy. Epileptic encephalopathy is used to …

Sodium channelopathies in neurodevelopmental disorders

MH Meisler, SF Hill, W Yu - Nature Reviews Neuroscience, 2021 - nature.com
The voltage-gated sodium channel α-subunit genes comprise a highly conserved gene
family. Mutations of three of these genes, SCN1A, SCN2A and SCN8A, are responsible for a …

[HTML][HTML] Structural basis of Nav1. 7 inhibition by a gating-modifier spider toxin

H Xu, T Li, A Rohou, CP Arthur, F Tzakoniati, E Wong… - Cell, 2019 - cell.com
Voltage-gated sodium (Nav) channels are targets of disease mutations, toxins, and
therapeutic drugs. Despite recent advances, the structural basis of voltage sensing …

Epilepsy-related voltage-gated sodium channelopathies: a review

LFS Menezes, EF Sabiá Júnior, DV Tibery… - Frontiers in …, 2020 - frontiersin.org
Epilepsy is a disease characterized by abnormal brain activity and a predisposition to
generate epileptic seizures, leading to neurobiological, cognitive, psychological, social, and …

Animal toxins—Nature's evolutionary-refined toolkit for basic research and drug discovery

V Herzig, B Cristofori-Armstrong, MR Israel… - Biochemical …, 2020 - Elsevier
Venomous animals have evolved toxins that interfere with specific components of their
victim's core physiological systems, thereby causing biological dysfunction that aids in prey …

Epilepsy genetics: clinical impacts and biological insights

CA Ellis, S Petrovski, SF Berkovic - The Lancet Neurology, 2020 - thelancet.com
Genomics now has an increasingly important role in neurology clinics. Regarding the
epilepsies, innovations centred around technology, analytics, and collaboration have led to …

Sodium channelopathies of skeletal muscle and brain

M Mantegazza, S Cestèle… - Physiological …, 2021 - journals.physiology.org
Voltage-gated sodium channels initiate action potentials in nerve, skeletal muscle, and other
electrically excitable cells. Mutations in them cause a wide range of diseases. These …

Antibodies and venom peptides: new modalities for ion channels

H Wulff, P Christophersen, P Colussi… - Nature Reviews Drug …, 2019 - nature.com
Ion channels play fundamental roles in both excitable and non-excitable tissues and
therefore constitute attractive drug targets for myriad neurological, cardiovascular and …