Schizophrenia is a psychiatric disorder which has a lifetime prevalence of~ 1%. Multiple
candidate mechanisms have been proposed in the pathogenesis of schizophrenia. One …

Mature multiciliated ependymal cells line the cerebral ventricles where they form a partial
barrier between the cerebrospinal fluid (CSF) and brain parenchyma and regulate local CSF …

Microglia, the immune cells of the brain, are important for neurodevelopment and have been
hypothesized to play a role in the pathogenesis of schizophrenia (SCZ). Although previous …

Background Stress precipitates mood disorders, characterized by a range of symptoms
present in different combinations, suggesting the existence of disease subtypes. Using an …

The development of depressive disorders had long been attributed to monoamine
variations, and pharmacological treatment strategies likewise focused on methods of …

Various neuropathological findings have been reported in bipolar disorder (BD). However, it
is unclear which findings are well established. To address this gap, we carried out a …

Several recent research findings indicate that schizophrenia (SCZ) may begin with an
abnormal neuro-genesis from embryonic Neural Stem Cells (NSCs) and that this process …

Clinical and pre-clinical studies have demonstrated an important role of neuroinflammation
in the etiology of schizophrenia. While the underlying mechanisms remain poorly …

Postnatal and adult neurogenesis in the subventricular zone and subgranular zone of
animals such as rodents and non‐human primates has been observed with many different …

Chronic inflammation of the central nervous system (CNS) is critical to the pathogenesis of
neuropsychiatric disorders (NPDs) that affect the global population. Current therapeutics for …