Kinins are a family of peptides implicated in several pathophysiological events. Most of their
effects are likely mediated by the activation of two G‐protein‐coupled receptors: B1 and B2 …

Background—Although the renin–angiotensin and the β-adrenergic systems are
interrelated, a direct interaction between β-adrenergic receptors (βARs) and angiotensin II …

Alteration in [Ca2+] i (the intracellular concentration of Ca2+) is a key regulator of many
cellular processes. To allow precise regulation of [Ca2+] i and a diversity of signalling by this …

Kinins are generated within inflammatory tissue microenvironments, where they exert
diverse functions, including cell proliferation, leukocyte activation, cell migration, endothelial …

Autocrine, paracrine, endocrine, and neuroendocrine hormonal systems help regulate
cardio‐vascular and renal function. Any change in the balance among these systems may …

Introduction: Kinins are peptide mediators exerting their pro-inflammatory actions by the
selective stimulation of two distinct G-protein coupled receptors, termed BKB1R and BKB2R …

Cell surface receptors are important proteins that mediate communication between the cells
and their outside environment, and also play essential roles in the control of a wide variety of …

The kallikrein–kinin system (KKS) is proposed to act as a counter regulatory system against
the vasopressor hormonal systems such as the renin-angiotensin system (RAS) …

Gα13 and Gα12, encoded by the GNA13 and GNA12 genes, respectively, are members of
the G12 family of Gα proteins that, along with their associated Gβγ subunits, mediate …

In 1980/81 Agnati and Fuxe introduced the concept of intramembrane receptor–receptor
interactions and presented the first experimental observations for their existence in crude …