The intriguing structural diversity in folded topologies available to guanine-rich nucleic acid
repeat sequences have made four-stranded G-quadruplex structures the focus of both basic …

In this review, we give an overview of recent literature on the structure and stability of
unimolecular G-rich quadruplex structures that are relevant to drug design and for in vivo …

Over the past decade, nucleic acid chemists have seen the spectacular emergence of
molecules designed to interact efficiently and selectively with a peculiar DNA structure …

Guanine‐rich sequences of DNA can assemble into tetrastranded structures known as G‐
quadruplexes. It has been suggested that these secondary DNA structures could be …

There are many structures that can be adopted by nucleic acids other than the famous
Watson–Crick duplex form. This tutorial review describes the guanine rich G-quadruplex …

G-rich DNA and RNA sequences can form four-stranded structures called G-quadruplexes.
Such structures have gained significant interest in the past decade with increasing evidence …

Telomeres are present at the ends of all eukaryotic chromosomes. Human telomeres play an
important role in critical processes underlying genome stability, cancer, and aging, and their …

Phen‐DC3 is a highly promising compound that specifically targets G‐quadruplexes, with
potent biological effects observed in vivo. We used NMR spectroscopy to solve the structure …

DNA is considered an important target for drug design and development. Until recently, the
focus was on double-stranded (duplex) DNA structures. However, it has now been shown …

The excessive production of reactive oxygen species (ROS) can lead to single nucleic acid
base damage, DNA strand breakage, inter-and intra-strand cross-linking of nucleic acids …