[HTML][HTML] Immunocompetent cancer-on-chip models to assess immuno-oncology therapy
TI Maulana, E Kromidas, L Wallstabe… - Advanced Drug Delivery …, 2021 - Elsevier
The advances in cancer immunotherapy come with several obstacles, limiting its
widespread use and benefits so far only to a small subset of patients. One of the underlying …
widespread use and benefits so far only to a small subset of patients. One of the underlying …
[HTML][HTML] Towards the development of human immune-system-on-a-chip platforms
Highlights•Immune system plays a critical role in maintaining homeostasis of the human
body.•Development of immune-system-on-a-chip platforms is in its infancy.•Several …
body.•Development of immune-system-on-a-chip platforms is in its infancy.•Several …
Combinatorial treatment rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas
Activated B-cell-like diffuse large B-cell lymphomas (ABC-DLBCLs) are characterized by
constitutive activation of nuclear factor κB driven by the B-cell receptor (BCR) and Toll-like …
constitutive activation of nuclear factor κB driven by the B-cell receptor (BCR) and Toll-like …
Extracellular matrix in synthetic hydrogel‐based prostate cancer organoids regulate therapeutic response to EZH2 and DRD2 inhibitors
Following treatment with androgen receptor (AR) pathway inhibitors,≈ 20% of prostate
cancer patients progress by shedding their AR‐dependence. These tumors undergo …
cancer patients progress by shedding their AR‐dependence. These tumors undergo …
A novel patient-derived 3D model recapitulates mantle cell lymphoma lymph node signaling, immune profile and in vivo ibrutinib responses
Mantle cell lymphoma (MCL), a rare and aggressive B-cell non-Hodgkin lymphoma, mainly
develops in the lymph node (LN) and creates a protective and immunosuppressive niche …
develops in the lymph node (LN) and creates a protective and immunosuppressive niche …
Human immune organoids to decode B cell response in healthy donors and patients with lymphoma
Antibodies are produced when naive B cells differentiate into plasma cells within germinal
centres (GCs) of lymphoid tissues. Patients with B cell lymphoma on effective …
centres (GCs) of lymphoid tissues. Patients with B cell lymphoma on effective …
Multiscale engineering of immune cells and lymphoid organs
Immunoengineering applies quantitative and materials-based approaches for the
investigation of the immune system and for the development of therapeutic solutions for …
investigation of the immune system and for the development of therapeutic solutions for …
Ex vivo tumor‐on‐a‐chip platforms to study intercellular interactions within the tumor microenvironment
V Kumar, S Varghese - Advanced healthcare materials, 2019 - Wiley Online Library
The emergence of immunotherapies and recent FDA approval of several of them makes
them a promising therapeutic strategy for cancer. While these advancements underscore the …
them a promising therapeutic strategy for cancer. While these advancements underscore the …
Intestinal organ chips for disease modelling and personalized medicine
Alterations in intestinal structure, mechanics and physiology underlie acute and chronic
intestinal conditions, many of which are influenced by dysregulation of microbiome …
intestinal conditions, many of which are influenced by dysregulation of microbiome …
Spatiotemporal dissection of tumor microenvironment via in situ sensing and monitoring in tumor-on-a-chip
Real-time monitoring in the tumor microenvironment provides critical insights of cancer
progression and mechanistic understanding of responses to cancer treatments. However …
progression and mechanistic understanding of responses to cancer treatments. However …