SYNBIP 2.0: epitopes mapping, sequence expansion and scaffolds discovery for synthetic binding protein innovation

Y Li, F Li, Z Duan, R Liu, W Jiao, H Wu… - Nucleic Acids …, 2025 - academic.oup.com
Synthetic binding proteins (SBPs) represent a pivotal class of artificially engineered proteins,
meticulously crafted to exhibit targeted binding properties and specific functions. Here, the …

Data and AI-driven synthetic binding protein discovery

Y Li, Z Duan, Z Li, W Xue - Trends in Pharmacological Sciences, 2025 - cell.com
Synthetic binding proteins (SBPs) are a class of protein binders that are artificially created
and do not exist naturally. Their broad applications in tackling challenges of research …

Engineering the Mechanical Stability of a Therapeutic Complex between Affibody and Programmed Death-Ligand 1 by Anchor Point Selection

B Yang, DEB Gomes, Z Liu, MS Santos, J Li… - ACS …, 2024 - ACS Publications
Protein–protein complexes can vary in mechanical stability depending on the direction from
which force is applied. Here, we investigated the mechanical stability of a complex between …

Atomistic Insights into gp82 Binding: A Microsecond, Million-Atom Exploration of Trypanosoma cruzi Host-Cell Invasion

RSL Rosa, M Leal da Silva, RC Bernardi - bioRxiv, 2024 - biorxiv.org
Chagas disease, caused by the protozoan Trypanosoma cruzi, affects millions globally,
leading to severe cardiac and gastrointestinal complications in its chronic phase. The …

Engineering the Mechanical Stability of a Therapeutic Affibody/PD-L1 Complex by Anchor Point Selection

B Yang, DEB Gomes, Z Liu, MS Santos, J Li… - …, 2024 - pmc.ncbi.nlm.nih.gov
Protein-protein complexes can vary in mechanical stability depending on the direction from
which force is applied. Here we investigated the anisotropic mechanical stability of a …

Amber Codon Mutational Scanning and Bioorthogonal PEGylation for Mapping Antibody Binding Sites on Human Arginase-1

J Fernandez de Santaella, NG Koch, L Widmer… - bioRxiv, 2024 - biorxiv.org
Epitope mapping is crucial for understanding immunological responses to protein
therapeutics. Here, we combined genetic code expansion and bacterial surface display to …