The placenta is essential for normal in utero development in mammals. In humans, defective
placental formation underpins common pregnancy disorders such as pre-eclampsia and …

Three versions of syncytiotrophoblast exist in the human placenta: an invasive type
associated with the implanting conceptus, non-invasive villous type of definitive placenta …

The placenta is a transient but important multifunctional organ crucial for healthy pregnancy
for both mother and fetus. Nevertheless, limited access to human placenta samples and the …

Direct in vivo investigation of human placenta trophoblast's susceptibility to SARS-CoV-2 is
challenging. Here we report that human trophoblast stem cells (hTSCs) and their derivatives …

Zika virus (ZIKV) drew worldwide attention when a recent epidemic was linked to fetal
microcephaly. Here we used human embryonic stem cell derived trophoblasts as a model …

Abstract The Bone Morphogenetic Protein (BMP) signaling pathway has established roles in
early embryonic morphogenesis, particularly in the epiblast. More recently, however, it has …

The trophectoderm layer of the blastocyst-stage embryo is the precursor for all trophoblast
cells in the placenta. Human trophoblast stem (TS) cells have emerged as an attractive tool …

The placenta, being a temporary organ, plays a crucial role in facilitating the exchange of
nutrients and gases between the mother and the fetus during pregnancy. Any abnormalities …

Most eukaryotic genes produce alternative polyadenylation (APA) isoforms. Here we report
that, unlike previously characterized cell lineages, differentiation of syncytiotrophoblast …

We describe a model for early onset preeclampsia (EOPE) that uses induced pluripotent
stem cells (iPSCs) generated from umbilical cords of EOPE and control (CTL) pregnancies …