Paclitaxel is an antineoplastic agent derived from the bark of the western yew, Taxus
brevifolia, with a broad spectrum of activity. Because paclitaxel promotes microtubule …

Growth cones are highly motile structures at the end of neuronal processes, capable of
receiving multiple types of guidance cues and transducing them into directed axonal growth …

Development of the Nervous System presents a broad and basic treatment of the
established and evolving principles of neural development as exemplified by key …

Abstract Development of the nervous system depends on the correct pathfinding and target
recognition by the growing tip of an axon, the growth cone,,. Diffusible or substrate-bound …

The possible role of cyclic nucleotides as second messengers mediating growth cone
turning was studied by producing an asymmetric distribution of cyclic nucleotides across the …

Pathfinding of growing neurites depends on turning of the growth cone in response to
extracellular cues. Motile filopodia of the growth cone are known to be critical for mediating …

A cDNA library constructed from mRNA of rat brain was used to clone the cDNA that
encodes the 30-kDa heparin-binding protein (amphoterin) that is developmentally regulated …

X-linked lissencephaly is a severe brain malformation affecting males. Recently it has been
demonstrated that the doublecortin gene is implicated in this disorder. In order to study the …

Polypyrrole (PPy) is an inherently conducting polymer that has shown great promise for
biomedical applications within the nervous system. However, to effectively use PPy as a …

To characterize CNS neuronal precursor migration along astroglial fibers, we examined the
motility of the migratory leading process and cytoskeletal-based mechanisms of locomotion …