The worldwide occurrence of diabetic kidney disease (DKD) is swiftly rising, primarily
attributed to the growing population of individuals affected by type 2 diabetes. This surge …

Diabetic kidney disease, known as a glomerular disease, arises from a metabolic disorder
impairing renal cell function. Mitochondria, crucial organelles, play a key role in substance …

Enabling the early detection and prevention of diabetic kidney damage has potential to
substantially reduce the global burden of kidney failure. There is a critical need for …

Cyclic di-guanosine monophosphate (c-di-GMP) is a bacterial second messenger that
governs the lifestyle switch between planktonic and biofilm states. While substantial …

Diabetic nephropathy (DN) also known as diabetic kidney disease, is a major microvascular
complication of diabetes and a leading cause of end‑stage renal disease (ESRD), which …

Background Peritoneal dialysis (PD) helps prevent lethal complications of end-stage renal
disease (ESRD). However, the clinical outcomes are affected by PD-related complications …

Senescent cell accumulation contributes to the progression of age-related disorders
including Alzheimer's disease (AD). Clinical trials evaluating senolytics, drugs that clear …

Endogenous adenine as a key player in diabetic kidney disease progression: an integrated
multiomics approach Endogenous adenine as a key player in diabetic kidney disease …

Kidney dysfunction often leads to neurological impairment, yet the complex kidney-brain
relationship remains elusive. We employed spatial and bulk metabolomics to investigate a …

Chronic kidney disease (CKD) affects approximately 13% of the global population.[1] CKD
contributes to kidney dysfunction and eventually progresses to end-stage kidney disease. In …