The members of the Src family of nonreceptor tyrosine kinases (SFKs) are implicated in
multiple signaling processes that regulate key cellular functions, including proliferation …

Stem cells have a high potential to impact regenerative medicine. However, stem cells in
adult tissues often proliferate at very slow rates. During development, stem cells may change …

Background Curcumin is a polyphenolic compound with potent chemopreventive and anti-
cancer efficacy. Purpose To explore the potential anti-metastasis efficacy of curcumin in …

Pomegranate (Punica granatum L.) is known to possess anticancer activities. The effects of
a standardized extract of pomegranate (PE) on a mouse mammary cancer cell line …

The Notch signaling pathway appears to be responsible for maintaining a balance between
cell proliferation and apoptosis and thus it has been suggested that Notch may play an …

Introduction Tumor-initiating cells (TIC) are being extensively studied for their role in tumor
etiology, maintenance and resistance to treatment. The isolation of TICs has been limited by …

Abstract Type 2 transglutaminase (TG2) is an important cancer stem cell survival protein that
exists in open and closed conformations. The major intracellular form is the closed …

Objective: Pancreatic cancer was the fourth leading cause of cancer death in the United
States in 2010. Recurrence of disease after resection occurs because of neoplastic cell …

Since the discovery of stem cells, scientists have invested tremendous effort in establishing
in vitro culture conditions in order to maintain the self-renewal and efficient proliferative …

Through the classic study of genetics, much has been learned about the regulation and
progression of human disease. Specifically, cancer has been defined as a disease driven by …