The genetic landscape of Parkinson's disease (PD) is characterised by rare high penetrance
pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a …

Parkinson's disease (PD) is the second most important age-related neurodegenerative
disorder in developed societies, after Alzheimer's disease, with a prevalence ranging from …

General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

We conducted a meta-analysis of Parkinson's disease genome-wide association studies
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty …

Mutations in the glucocerebrosidase (GBA) gene, which encodes the lysosomal enzyme that
is deficient in Gaucher's disease, are important and common risk factors for Parkinson's …

Parkinson's disease (PD) is the second most prevalent neurological disorder and has been
the focus of intense investigations to understand its etiology and progression, but it still lacks …

The past 15 years has witnessed tremendous progress in our understanding of the genetic
basis for Parkinson's disease (PD). Notably, whereas most mutations, such as those in …

Summary Synaptojanin 1 (SJ1) is a major presynaptic phosphatase that couples synaptic
vesicle endocytosis to the dephosphorylation of PI (4, 5) P 2, a reaction needed for the …

Abstract The Ashkenazi Jewish (AJ) population is a genetic isolate close to European and
Middle Eastern groups, with genetic diversity patterns conducive to disease mapping. Here …

Chronic inflammation is a major characteristic feature of Parkinson's disease (PD). Studies
in PD patients show evidence of augmented levels of potent pro-inflammatory molecules eg …