Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid formed during the
metabolism of the essential amino acid methionine. Hcy is considered a risk factor for …

In the last 10 years, homocysteine has been regarded as a marker of cardiovascular disease
and a definite risk factor for many other diseases. Homocysteine is biosynthesized from …

Increased levels of homocysteine have been established as a risk factor for cardiovascular
disease (CVD) by mechanisms still incompletely defined. S-Adenosylhomocysteine (SAH) is …

Hyperhomocysteinemia occurs in chronic-and end-stage kidney disease at the time when
dialysis or transplant becomes indispensable for survival. Excessive accumulation of …

The methylation of arginine residues by protein arginine methyltransferases (PRMTs) is a
type of post-translational modification which is important for numerous cellular processes …

The therapeutic effect of irradiation is thought to come from DNA damage that affects rapidly
proliferating cancer cells; however, resistant cells rapidly initiate mechanisms to repair such …

S-Adenosylhomocysteine (SAH) is a negative regulator of most methyltransferases and the
precursor for the cardiovascular risk factor homocysteine. We have previously identified a …

Cardiac fibrosis is characterized by net accumulation of extracellular matrix (ECM) proteins
in the cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many …

Aquaporins (AQPs) are transmembrane channels that facilitate water and glycerol
permeation through cell membranes. Recently, the water channel AQP1 was suggested to …

Accumulation of the homocysteine (Hcy) precursor S-adenosylhomocysteine (AdoHcy) may
cause cellular hypomethylation in the setting of hyperhomocysteinemia because of …