MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies

SE Ahmadi, S Rahimi, B Zarandi, R Chegeni… - Journal of hematology & …, 2021 - Springer
MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

Alternative approaches to target Myc for cancer treatment

C Wang, J Zhang, J Yin, Y Gan, S Xu, Y Gu… - Signal transduction and …, 2021 - nature.com
The Myc proto-oncogene family consists of three members, C-MYC, MYCN, and MYCL,
which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and L-Myc …

Myc and cell cycle control

G Bretones, MD Delgado, J León - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
Soon after the discovery of the Myc gene (c-Myc), it became clear that Myc expression levels
tightly correlate to cell proliferation. The entry in cell cycle of quiescent cells upon Myc …

MYC oncogene contributions to release of cell cycle brakes

L García-Gutiérrez, MD Delgado, J León - Genes, 2019 - mdpi.com
Promotion of the cell cycle is a major oncogenic mechanism of the oncogene c-MYC (MYC).
MYC promotes the cell cycle by not only activating or inducing cyclins and CDKs but also …

MYC degradation

AS Farrell, RC Sears - Cold Spring …, 2014 - perspectivesinmedicine.cshlp.org
The MYC oncoprotein is an essential transcription factor that regulates the expression of
many genes involved in cell growth, proliferation, and metabolic pathways. Thus, it is …

Multiple functions of p27 in cell cycle, apoptosis, epigenetic modification and transcriptional regulation for the control of cell growth: A double-edged sword protein

M Abbastabar, M Kheyrollah, K Azizian, N Bagherlou… - DNA repair, 2018 - Elsevier
The cell cycle is controlled by precise mechanisms to prevent malignancies such as cancer,
and the cell needs these tight and advanced controls. Cyclin dependent kinase inhibitor p27 …

Regulation of gene transcription by the oncoprotein MYC

B Lüscher, J Vervoorts - Gene, 2012 - Elsevier
The proteins of the MYC/MAX/MAD network are central regulators of many key processes
associated with basic cell physiology. These include the regulation of protein biosynthesis …

p27Kip1 signaling: Transcriptional and post-translational regulation

SST Hnit, C Xie, M Yao, J Holst, A Bensoussan… - The international journal …, 2015 - Elsevier
Abstract p27 Kip1 is an inhibitor of a broad spectrum of cyclin-dependent kinases (CDKs),
and the loss of a single p27 Kip1 allele is thereby sufficient to increase tumor incidence via …

The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling

T Okada, S Sinha, I Esposito, G Schiavon… - Nature cell …, 2015 - nature.com
Abstract We identified the Rho GTPase Rnd1 as a candidate metastasis suppressor in basal-
like and triple-negative breast cancer through bioinformatics analysis. Depletion of Rnd1 …

Skp2: a novel potential therapeutic target for prostate cancer

Z Wang, D Gao, H Fukushima, H Inuzuka, P Liu… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Prostate cancer is the most frequently diagnosed tumor in men and the second most
common cause of cancer-related death for males in the United States. It has been shown …