14-and 15-membered lactone macrolides and their analogues and hybrids: Structure, molecular mechanism of action and biological activity

A Janas, P Przybylski - European journal of medicinal chemistry, 2019 - Elsevier
Abstract Classical macrolides containing 14-or 15-membered aglycone lactone rings are
basic and widely used antibacterial agents in clinical therapy. Macrolides exert antibacterial …

Thiophene‐containing compounds with antimicrobial activity

G Roman - Archiv der Pharmazie, 2022 - Wiley Online Library
Thiophene, as a member of the group of five‐membered heterocycles containing one
heteroatom, is one of the simplest heterocyclic systems. Many synthetic strategies allow the …

Synthesis, spectral, antioxidant, in vitro cytotoxicity activity and thermal analysis of Schiff base metal complexes with 2, 2′-Bipyridine-4, 4′-dicarboxylic acid as co …

P Mahadevi, S Sumathi, A Metha, J Singh - Journal of Molecular Structure, 2022 - Elsevier
The Schiff base ligand (H 2 L 1)[H 2 L 1=(E)-2-hydroxy-N'-((2-hydroxynaphthalen-1-yl)-
methylene) benzo hydrazide] and its metal (II) complexes of molecular formula [Co (H 2 L …

Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2‐Hydroxy‐3‐(hydroxyimino)‐4‐oxopentan‐2‐ylidene) benzohydrazide

AS El-Tabl, M Mohamed Abd El-Waheed… - Bioinorganic …, 2015 - Wiley Online Library
Novel metal (II) complexes derived from 2‐hydroxy‐N′‐((Z)‐3‐(hydroxyimino)‐4‐
oxopentan‐2‐ylidene) benzohydrazide ligand (H2L) were synthesized and characterized by …

Design, synthesis and structure-activity relationships of novel non-ketolides: 9-Oxime clarithromycin featured with seven-to thirteen-atom-length diamine linkers at 3 …

CX Ma, WT Liu, XM Li, J Ding, SM Liu, F Xue… - European Journal of …, 2024 - Elsevier
We report here on the structure-activity relationships of hybrids combining 3-descladinosyl
clarithromycin with quinolones linked by extended diamine connectors. Several hybrids …

Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of …

BZ Fan, H Hiasa, W Lv, S Brody, ZY Yang… - European Journal of …, 2020 - Elsevier
In the search for novel hybrid molecules by fusing two biologically active scaffolds into one
heteromeric chemotype, we found that hybrids of azithromycin and ciprofloxacin/gatifloxacin …

Structure-activity relationships and mechanism of action of macrolides derived from erythromycin as antibacterial agents

JH Liang, X Han - Current Topics in Medicinal Chemistry, 2013 - ingentaconnect.com
Structure-Activity Relationships and Mechanism of Action of Macrolides Derived from
Erythromycin as Antibacterial Agents Page 1 Send Orders for Reprints to reprints@benthamscience.net …

Synthesis, characterization, antibacterial, anticancer, and density‐functional theory studies of nano‐metal (II) oxime complexes

EN Al‐Sabawi, ASM Al‐Janabi… - Applied …, 2022 - Wiley Online Library
New nanophenolic oxime complexes of the type [M (κ2‐Saly) 2]{where HSaly= salicyl‐
aldoxime; M= Co (1), Ni (2), Cu (3), Pd (4), Pt (5), Zn (6), Cd (7), and Hg (8)} were prepared …

Recent advancements in macrolide hybrids against Staphylococcus aureus

C Ji, X Xu - Current Topics in Medicinal Chemistry, 2021 - ingentaconnect.com
Staphylococcus aureus (S. aureus), recognized as one of the deadliest pathogens
responsible for nosocomial and community acquired infections, is highly contagious and …

Transition metal complexes of N′-(2-(hydroxyimino) propanoyl) isonicotinohydrazide: Synthesis, characterization, DNA interaction and anticancer evaluation

D Hegde, GN Naik, RS Vadavi, S Kumar… - Inorganica Chimica …, 2017 - Elsevier
A new tetradentate chelating ligand, N′-(2-(hydroxyimino) propanoyl) isonicotinohydrazide
and its selective transition metal complexes have been synthesized and evaluated for …